Omectatug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:13:06 GMT 2025` Edited by `admin` on `Wed Apr 02 19:13:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	QZ3WR2DNM3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Omectatug

Official Name

English

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV1-8*01 (85.7%) -(IGHD) -IGHJ6*01 (85.7%) G119>D (109), CDR-IMGT [8.8.11] (26-33.51-58.97-107))(1-118) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (215) (119-216), hin

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody (Omectatug)

Common Name

English

omectatug [INN]

Common Name

English

Immunoglobulin G1, anti-(human claudin CLDN18.2) (human-Mus musculus monoclonal ASKB589 ?1-chain), disulfide with human-Mus musculus monoclonal ASKB589 ?-chain, dimer

Common Name

English

Code System Code Type Description

INN

13058

Created by admin on Wed Apr 02 19:13:06 GMT 2025 , Edited by admin on Wed Apr 02 19:13:06 GMT 2025

PRIMARY

NCI_THESAURUS

C179328

Created by admin on Wed Apr 02 19:13:06 GMT 2025 , Edited by admin on Wed Apr 02 19:13:06 GMT 2025

PRIMARY

SMS_ID

300000054936

Created by admin on Wed Apr 02 19:13:06 GMT 2025 , Edited by admin on Wed Apr 02 19:13:06 GMT 2025

PRIMARY

CAS

2867393-44-8

Created by admin on Wed Apr 02 19:13:06 GMT 2025 , Edited by admin on Wed Apr 02 19:13:06 GMT 2025

PRIMARY

FDA UNII

QZ3WR2DNM3

Created by admin on Wed Apr 02 19:13:06 GMT 2025 , Edited by admin on Wed Apr 02 19:13:06 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_220
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_221	3_220
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					O86SW5D7BQ

CLAUDIN 18 SPLICE VARIANT 2

TARGET->LIGAND

Amount:

Related Record Type Details


					QZ3WR2DNM3

Omectatug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL