Sigvotatug Vedotin

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:46:25 GMT 2025` Edited by `admin` on `Wed Apr 02 06:46:25 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	QX0ONY0O9T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sigvotatug Vedotin

Official Name

English

SGN-B6A

Preferred Name

English

Immunoglobulin G1, anti-(human integrin ?6) (human-Mus musculus monoclonal h2A2 ?1-chain), disulfide with human-Mus musculus monoclonal h2A2 ?-chain, dimer, reduced, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]

Systematic Name

English

sigvotatug vedotin [INN]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens ITGB6 (integrin subunit beta 6)], humanized monoclonal antibody, conjugated on an average of 4 cysteinyl residues via a cleavable linker to monomethylauristatin E (MMAE)

Common Name

English

SGNB6A

Code

English

SIGVOTATUG VEDOTIN [USAN]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens ITGB6 (integrin subunit beta 6)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (79.6%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-1

Systematic Name

English

Sigvotatug vedotin [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

QX0ONY0O9T

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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CAS

2764774-91-4

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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INN

12757

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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USAN

MN-202

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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NCI_THESAURUS

C203047

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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SMS_ID

300000022193

Created by admin on Wed Apr 02 06:46:25 GMT 2025 , Edited by admin on Wed Apr 02 06:46:25 GMT 2025

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From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_366	2_424
2_260	2_320
2_219	4_214
2_143	2_199
2_22	2_96
1_366	1_424
1_260	1_320
1_228	2_228
1_225	2_225
1_219	3_214
1_143	1_199
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					ZD7KM155DD

PARENT -> CONJUGATE

Amount:


					C3QS75G3YQ

INTEGRIN BETA-6

TARGET->LIGAND

Amount:

Related Record Type Details


					QX0ONY0O9T

Sigvotatug Vedotin

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
		PARTIAL REDUCTION OF DISULFIDE BONDS		TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE	H49AAM893K

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
PARTIAL REDUCTION OF DISULFIDE BONDS	[1_219] [1_225] [1_228] [2_219] [2_225] [2_228] [3_214] [4_214]	SITE_SPECIFIC		Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL