U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:45:27 GMT 2023
Edited
by admin
on Sat Dec 16 15:45:27 GMT 2023
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMANIZED
Sequence Type COMPLETE
Record UNII
QX0ONY0O9T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Sigvotatug vedotin
INN  
Official Name English
Immunoglobulin G1, anti-(human integrin β6) (human-Mus musculus monoclonal h2A2 γ1-chain), disulfide with human-Mus musculus monoclonal h2A2 κ-chain, dimer, reduced, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohex
Common Name English
sigvotatug vedotin [INN]
Common Name English
Immunoglobulin G1-kappa, anti-[Homo sapiens ITGB6 (integrin subunit beta 6)], humanized monoclonal antibody, conjugated on an average of 4 cysteinyl residues via a cleavable linker to monomethylauristatin E (MMAE)
Common Name English
Code System Code Type Description
FDA UNII
QX0ONY0O9T
Created by admin on Sat Dec 16 15:45:28 GMT 2023 , Edited by admin on Sat Dec 16 15:45:28 GMT 2023
PRIMARY
CAS
2764774-91-4
Created by admin on Sat Dec 16 15:45:28 GMT 2023 , Edited by admin on Sat Dec 16 15:45:28 GMT 2023
PRIMARY
INN
12757
Created by admin on Sat Dec 16 15:45:28 GMT 2023 , Edited by admin on Sat Dec 16 15:45:28 GMT 2023
PRIMARY
From To
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
2_366 2_424
2_260 2_320
2_219 4_214
2_143 2_199
2_22 2_96
1_366 1_424
1_260 1_320
1_228 2_228
1_225 2_225
1_219 3_214
1_143 1_199
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
PARENT -> CONJUGATE
TARGET->LIGAND
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL