TRANSFLUTHRIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H12Cl2F4O2
Molecular Weight	371.154
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC2=C(F)C(F)=CC(F)=C2F

InChI

InChIKey=DDVNRFNDOPPVQJ-HQJQHLMTSA-N

InChI=1S/C15H12Cl2F4O2/c1-15(2)7(3-10(16)17)11(15)14(22)23-5-6-12(20)8(18)4-9(19)13(6)21/h3-4,7,11H,5H2,1-2H3/t7-,11+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C15H12Cl2F4O2
Molecular Weight	371.154
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27527601
Curator's Comment: Description was created based on several sources, including http://medind.nic.in/iad/t15/i1/iadt15i1p47.htm

Transfluthrin is a synthetic pyrethroid insecticide, available in the market as 0.88% w/w liquid vaporiser. It is a repellent insecticide, generally used for the control of mosquitoes in the household. It is also the primary insecticide in certain products for killing wasps and hornets, including their nests.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochrome P450 2E1 25 Target ID: CHEMBL5978 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22080754	Activator 1430
Cytochrome P450 3A2 1 Target ID: CHEMBL3324 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22080754	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Monitoring of allethrin, deltamethrin, esbiothrin, prallethrin and transfluthrin in air during the use of household mosquito repellents.	2001 Feb	11354726
Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats.	2006 May-Jun	16552726
The photochemical behaviour of five household pyrethroid insecticides and a synergist as studied by photo-solid-phase microextraction.	2007 Jul	17492275
A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides.	2008 Feb	17949707
Malaria prevention in north-eastern Tanzania: patterns of expenditure and determinants of demand at the household level.	2009 May 7	19422704
Pressurized liquid extraction and cleanup procedure for the determination of pyrethroids in soils using gas chromatography/tandem mass spectrometry.	2010	20410569

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Transfluthrin (0.05, 0.1, 0.5, 0.75, and 1.0 mmol) has a genotoxic effect on the epithelial cells of human nasal mucosa.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:58:09 GMT 2023` Edited by `admin` on `Sat Dec 16 05:58:09 GMT 2023`
Record UNII	QWL3SKA6EG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRANSFLUTHRIN

Common Name

English

2,3,5,6-TETRAFLUOROBENZYL (+)-(1R-TRANS)-2,2-DIMETHYL-3-(2,2-DICHLOROVINYL)CYCLOPROPANECARBOXYLATE

Systematic Name

English

(2,3,5,6-TETRAFLUOROPHENYL) METHYL (1R)-TRANS-3-(2,2-DICHLOROVINYL)-2,2-DIMETHYLCYCLOPROPANE-CARBOXYLATE

Common Name

English

BAYOTHRIN

Brand Name

English

TRANSFLUTHRIN [JAN]

Common Name

English

CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R-TRANS)-

Common Name

English

CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R,3S)-

Common Name

English

TRANSFLUTHRIN [ISO]

Common Name

English

BENFLUTHRIN

Brand Name

English

Code System Code Type Description

DRUG BANK

DB15117