TRANSFLUTHRIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H12Cl2F4O2
Molecular Weight	371.154
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC2=C(F)C(F)=CC(F)=C2F

InChI

InChIKey=DDVNRFNDOPPVQJ-HQJQHLMTSA-N

InChI=1S/C15H12Cl2F4O2/c1-15(2)7(3-10(16)17)11(15)14(22)23-5-6-12(20)8(18)4-9(19)13(6)21/h3-4,7,11H,5H2,1-2H3/t7-,11+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C15H12Cl2F4O2
Molecular Weight	371.154
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27527601
Curator's Comment: Description was created based on several sources, including http://medind.nic.in/iad/t15/i1/iadt15i1p47.htm

Transfluthrin is a synthetic pyrethroid insecticide, available in the market as 0.88% w/w liquid vaporiser. It is a repellent insecticide, generally used for the control of mosquitoes in the household. It is also the primary insecticide in certain products for killing wasps and hornets, including their nests.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochrome P450 2E1 25 Target ID: CHEMBL5978 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22080754	Activator 1447
Cytochrome P450 3A2 1 Target ID: CHEMBL3324 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22080754	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Simultaneous determination of nine pyrethroids in indoor insecticide products by capillary gas chromatography.	2010-02-05	19875265
Pressurized liquid extraction and cleanup procedure for the determination of pyrethroids in soils using gas chromatography/tandem mass spectrometry.	2010	20410569
Simultaneous determination of 18 pyrethroids in indoor air by gas chromatography/mass spectrometry.	2009-06-26	19457492
Malaria prevention in north-eastern Tanzania: patterns of expenditure and determinants of demand at the household level.	2009-05-07	19422704
Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides.	2009-01	19019354
Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.	2008-03	19325743
A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides.	2008-02	17949707
Efficacy of various pyrethroid structures against a highly metabolically resistant isogenic strain of Helicoverpa armigera (Lepidoptera: Noctuidae) from China.	2007-10	17685437
The photochemical behaviour of five household pyrethroid insecticides and a synergist as studied by photo-solid-phase microextraction.	2007-07	17492275
Multivariate optimization of the factors influencing the solid-phase microextraction of pyrethroid pesticides in water.	2006-08-18	16820159
Maternal hair--an appropriate matrix for detecting maternal exposure to pesticides during pregnancy.	2006-07	16584725
Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats.	2006-03-23	16552726
Genotoxic effects of pentachlorophenol, lindane, transfluthrin, cyfluthrin, and natural pyrethrum on human mucosal cells of the inferior and middle nasal conchae.	2005-06-01	15921213
Electron ionization gas chromatography-mass spectrometric determination of residues of thirteen pyrethroid insecticides in whole blood.	2004-04-05	15018801
Personal protection against mosquitoes in Dar es Salaam, Tanzania, by using a kerosene oil lamp to vaporize transfluthrin.	2002-09	12243228
Monitoring of allethrin, deltamethrin, esbiothrin, prallethrin and transfluthrin in air during the use of household mosquito repellents.	2001-02	11354726

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Transfluthrin (0.05, 0.1, 0.5, 0.75, and 1.0 mmol) has a genotoxic effect on the epithelial cells of human nasal mucosa.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:35:00 GMT 2025` Edited by `admin` on `Mon Mar 31 21:35:00 GMT 2025`
Record UNII	QWL3SKA6EG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRANSFLUTHRIN

Common Name

English

BAYOTHRIN

Preferred Name

English

2,3,5,6-TETRAFLUOROBENZYL (+)-(1R-TRANS)-2,2-DIMETHYL-3-(2,2-DICHLOROVINYL)CYCLOPROPANECARBOXYLATE

Systematic Name

English

(2,3,5,6-TETRAFLUOROPHENYL) METHYL (1R)-TRANS-3-(2,2-DICHLOROVINYL)-2,2-DIMETHYLCYCLOPROPANE-CARBOXYLATE

Common Name

English

TRANSFLUTHRIN [JAN]

Common Name

English

CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R-TRANS)-

Common Name

English

CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R,3S)-

Common Name

English

TRANSFLUTHRIN [ISO]

Common Name

English

BENFLUTHRIN

Brand Name

English

Code System Code Type Description

DRUG BANK

DB15117