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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H12Cl2F4O2
Molecular Weight 371.154
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRANSFLUTHRIN

SMILES

CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCC2=C(F)C(F)=CC(F)=C2F

InChI

InChIKey=DDVNRFNDOPPVQJ-HQJQHLMTSA-N
InChI=1S/C15H12Cl2F4O2/c1-15(2)7(3-10(16)17)11(15)14(22)23-5-6-12(20)8(18)4-9(19)13(6)21/h3-4,7,11H,5H2,1-2H3/t7-,11+/m1/s1

HIDE SMILES / InChI
Molecular Formula C15H12Cl2F4O2
Molecular Weight 371.154
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://medind.nic.in/iad/t15/i1/iadt15i1p47.htm

Transfluthrin is a synthetic pyrethroid insecticide, available in the market as 0.88% w/w liquid vaporiser. It is a repellent insecticide, generally used for the control of mosquitoes in the household. It is also the primary insecticide in certain products for killing wasps and hornets, including their nests.

CNS Activity

CNS Penetrant
2554
Curator's Comment: In humans after oral ingestion low levels of the transfluthrin are found in the brain

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Activator
1430
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Monitoring of allethrin, deltamethrin, esbiothrin, prallethrin and transfluthrin in air during the use of household mosquito repellents.
2001 Feb
Electron ionization gas chromatography-mass spectrometric determination of residues of thirteen pyrethroid insecticides in whole blood.
2004 Apr 5
Genotoxic effects of pentachlorophenol, lindane, transfluthrin, cyfluthrin, and natural pyrethrum on human mucosal cells of the inferior and middle nasal conchae.
2005 Mar-Apr
Maternal hair--an appropriate matrix for detecting maternal exposure to pesticides during pregnancy.
2006 Jul
Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats.
2006 May-Jun
Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.
2008 Mar
Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides.
2009 Jan
Simultaneous determination of 18 pyrethroids in indoor air by gas chromatography/mass spectrometry.
2009 Jun 26
Malaria prevention in north-eastern Tanzania: patterns of expenditure and determinants of demand at the household level.
2009 May 7
Pressurized liquid extraction and cleanup procedure for the determination of pyrethroids in soils using gas chromatography/tandem mass spectrometry.
2010
Simultaneous determination of nine pyrethroids in indoor insecticide products by capillary gas chromatography.
2010 Feb 5
Patents

Patents

JP2006070037A
1
JP2011509971A
151
JPH0543412A
1
JPH06192019A
1
JPH0839511A
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Transfluthrin (0.05, 0.1, 0.5, 0.75, and 1.0 mmol) has a genotoxic effect on the epithelial cells of human nasal mucosa.
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:58:09 GMT 2023
Edited
by admin
on Sat Dec 16 05:58:09 GMT 2023
Record UNII
QWL3SKA6EG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRANSFLUTHRIN
ISO   JAN  
Common Name English
2,3,5,6-TETRAFLUOROBENZYL (+)-(1R-TRANS)-2,2-DIMETHYL-3-(2,2-DICHLOROVINYL)CYCLOPROPANECARBOXYLATE
Systematic Name English
(2,3,5,6-TETRAFLUOROPHENYL) METHYL (1R)-TRANS-3-(2,2-DICHLOROVINYL)-2,2-DIMETHYLCYCLOPROPANE-CARBOXYLATE
Common Name English
BAYOTHRIN
Brand Name English
TRANSFLUTHRIN [JAN]
Common Name English
CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R-TRANS)-
Common Name English
CYCLOPROPANECARBOXYLIC ACID, 3-(2,2-DICHLOROETHENYL)-2,2-DIMETHYL-, (2,3,5,6-TETRAFLUOROPHENYL)METHYL ESTER, (1R,3S)-
Common Name English
TRANSFLUTHRIN [ISO]
Common Name English
BENFLUTHRIN
Brand Name English
Code System Code Type Description
DRUG BANK
DB15117
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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CAS
118712-89-3
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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CHEBI
32253
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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MESH
C560613
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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SMS_ID
100000151761
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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ALANWOOD
transfluthrin
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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EVMPD
SUB126158
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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WIKIPEDIA
TRANSFLUTHRIN
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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PUBCHEM
656612
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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FDA UNII
QWL3SKA6EG
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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EPA CompTox
DTXSID4046812
Created by admin on Sat Dec 16 05:58:09 GMT 2023 , Edited by admin on Sat Dec 16 05:58:09 GMT 2023
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NIH
NCATS
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