Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H19NO3.ClH |
| Molecular Weight | 321.799 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@@]12C=C[C@H](O)[C@@H]3OC4=C(OC)C=CC5=C4[C@]13CCN[C@@H]2C5
InChI
InChIKey=PNRHAWADPSUWEX-GBWBWFAWSA-N
InChI=1S/C17H19NO3.ClH/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16;/h2-5,10-12,16,18-19H,6-8H2,1H3;1H/t10-,11+,12-,16-,17-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H19NO3 |
| Molecular Weight | 285.3377 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Norcodeine is the N-demethylated derivative of codeine. It has relatively little opioid activity in its own right, but is formed as a metabolite of codeine following ingestion. Codeine and its other major metabolites codeine-6-glucuronide and norcodeine have weak affinity to opioid μ-receptors.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Human pharmacology and addiction liability of norcodeine. | 1960 Jun |
|
| Methadone maintenance and narcotic blocking drugs. Appendix. | 1977 Oct |
|
| High-performance liquid chromatographic study of codeine, norcodeine, and morphine as indicators of codeine ingestion. | 1984 Mar-Apr |
Patents
Sample Use Guides
In a "cross-over” test, norcodeine (75 mg/80 kg) was
given to 9 nontolerant subjects. Using a balanced cross-over plan, 5 nontolerant
subjects received, in a 30-hour period, five doses of norcodeine in one experiment and five doses of codeine in another, the successive doses of both
drugs being 75, 50, 50, 75 and 75 mg/80 kg.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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| Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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