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Details

Stereochemistry ACHIRAL
Molecular Formula C18H35O2.Na
Molecular Weight 306.4591
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sodium stearate

SMILES

[Na+].CCCCCCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=RYYKJJJTJZKILX-UHFFFAOYSA-M
InChI=1S/C18H36O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2-17H2,1H3,(H,19,20);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C18H35O2
Molecular Weight 283.4693
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Stearic Acid is a typical example of a fatty acid, which are essentially long hydrocarbon chains containing a carboxyl group at one end and a methyl group at the other. The chain lengths can vary from 3 (propionic acid) to 24 (lignoceric acid) but the majority of fatty acids found in hydrogenated vegetable or animal oils are around C16-C20 in length. Stearic acid is a saturated acid, since there are no double bonds between neighbouring carbon atoms. Stearic acid is found in various animal and plant fats, and is a major component of cocoa butter and shea butter. Stearic acid is a very common amino acid is used in the manufacturing of more than 3,200 skin and hair care products sold in the United States. On product labels, it is sometimes listed under other names, including Century 1240, cetylacetic acid, Emersol 120, Emersol 132, Emersol 150, Formula 300 and Glycon DP. Stearic Acid is mainly used in the production of detergents, soaps, and cosmetics such as shampoos and shaving cream products. Stearic acid is used along with castor oil for preparing softeners in textile sizing. Being inexpensively available and chemically benign, stearic acid finds many niche applications It is used in the manufacture of candles, and as a hardener in candies when mixed with simple sugar and corn syrup. It is also used to produce dietary supplements. In fireworks, stearic acid is often used to coat metal powders such as aluminum and iron. This prevents oxidation, allowing compositions to be stored for a longer period of time. Stearic acid is a common lubricant during injection molding and pressing of ceramic powders. It is also used as a mold release for foam latex that is baked in stone molds. Stearic acid is known antidiabetic and antioxidant agent.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
9.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
CELLBN First care cleanser

Approved Use

Unknown

Launch Date

1.49575683E12
Preventing
MARY KAY TIMEWISE REPAIR VOLU-FIRM THE GO SET

Approved Use

Uses: helps prevent sunburn if used as directed with other sun protection measures (see Directions), decreases the risk of skin cancer and early skin aging caused by the sun

Launch Date

1.5107904E12
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Prediction of drug content and hardness of intact tablets using artificial neural network and near-infrared spectroscopy.
2001 Aug
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells.
2001 Feb
Long-term stability characterization of a controlled release gastrointestinal therapeutic system coated with a cellulose acetate pseudolatex.
2001 Jan
An in vitro investigation of the suitability of press-coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting.
2001 Jan 29
Formulation and process optimization to eliminate picking from market image tablets.
2001 Mar 14
Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells.
2001 May
Plasma transport and tissue distribution of beta-carotene, vitamin A and retinol-binding protein in domestic cats.
2001 Nov
The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).
2001 Sep
Manganese absorption and retention in rats is affected by the type of dietary fat.
2001 Summer
Dietary cholesterol modulates delta6 and delta9 desaturase mRNAs and enzymatic activity in rats fed a low-eFA diet.
2002 Apr
Long-chain fatty acid uptake and oxidation in the perfused liver of Walker-256 tumour-bearing rats.
2002 Aug
A case of rhinolithiasis in botswana: a mineralogical, microscopic and chemical study.
2002 Dec
Different role of saturated and unsaturated fatty acids in beta-cell apoptosis.
2002 Dec 20
Design of Peumus boldus tablets by direct compression using a novel dry plant extract.
2002 Feb 21
Binding of [99mTc]chondroitin sulfate to scavenger receptors on human chondrocytes as compared to binding of oxidized [125I]LDL on human macrophages.
2002 Feb-Nov
The impact of low levels of amorphous material (<5%) on the blending characteristics of a direct compression formulation.
2002 Jan 14
Comparison of effects of cholecystokinin and erythromycin on bile chemistry and gallstone formation in aged guinea pigs.
2002 Jan-Feb
Fatty acid mobilized by the vascular endothelial growth factor in human endothelial cells.
2002 Nov
Synthesis and selectin-binding activity of N-deacetylsialyl Lewis X ganglioside.
2002 Nov 19
Molecular species of PC and PE formed during castor oil biosynthesis.
2002 Oct
Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.
2002 Oct
Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C.
2002 Oct
Mixing of cohesive pharmaceutical formulations in tote (bin) blenders.
2002 Sep
Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles.
2002 Sep
Inverse gas chromatography study on partially esterified paper fiber.
2002 Sep 6
Percutaneous absorption of inorganic lead compounds.
2002 Sep-Oct
Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug-excipient interactions.
2003 Feb 18
Spray-dried chitinosans. Part II: in vitro drug release from tablets made from spray-dried chitinosans.
2003 Feb 18
The influence of lipid nanocapsule composition on their size distribution.
2003 Jan
Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study.
2003 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: When these same investigators used a lower amount of dietary stearic acid (i.e., an increase of 3 g/day using milk chocolate) in a similar study, no differences in platelet aggregation or platelet activation activity were found
A stearic acid-rich diet (~ 7% of calories or 19 g/day) had beneficial effects on several measures of thrombosis (e.g., platelet volume, platelet aggregation, coagulation factor VII activity) in healthy males. Stearic acid was increased by 12 g/day using stearic acid-enriched margarine.
Route of Administration: Oral
Inhibition of EDR (endothelium-dependent relaxation) induced by acetylcholine was dose-dependent (0.5-2 mmol/l NEFA), and the greatest inhibition (51%) was observed with stearic acid (2 mmol/l).
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:11:50 UTC 2023
Edited
by admin
on Fri Dec 15 15:11:50 UTC 2023
Record UNII
QU7E2XA9TG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Sodium stearate
HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
SODIUM STEARATE [II]
Common Name English
OCTADECANOIC ACID, SODIUM SALT
Common Name English
NONSOUL SN 15
Common Name English
RHENOGRAN NAST 50ACMF-GE1858
Common Name English
SODIUM STEARATE [MI]
Common Name English
FLEXICHEM B
Common Name English
Sodium stearate [WHO-DD]
Common Name English
INS NO.470(I)STEARIC ACID, SODIUM SALT
Common Name English
SODIUM STEARATE [MART.]
Common Name English
SODIUM STEARATE [HSDB]
Common Name English
SODIUM STEARATE [VANDF]
Common Name English
E-470(I)STEARIC ACID, SODIUM SALT
Common Name English
EDENOR FHTI
Common Name English
INS-470(I)STEARIC ACID, SODIUM SALT
Common Name English
SODIUM STEARATE [INCI]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
JECFA EVALUATION INS-470(I)
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
EPA PESTICIDE CODE 79070
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
Code System Code Type Description
WIKIPEDIA
SODIUM STEARATE
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
CAS
822-16-2
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
CHEBI
132109
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
CONCEPT Industrial Aid
PUBCHEM
2724691
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
NCI_THESAURUS
C77501
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
DAILYMED
QU7E2XA9TG
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
MESH
C031183
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
HSDB
5759
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
MERCK INDEX
m10076
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID9027318
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
RXCUI
1366984
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY RxNorm
FDA UNII
QU7E2XA9TG
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
SMS_ID
100000086785
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
EVMPD
SUB20850
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
ECHA (EC/EINECS)
212-490-5
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
ChEMBL
CHEMBL1906423
Created by admin on Fri Dec 15 15:11:50 UTC 2023 , Edited by admin on Fri Dec 15 15:11:50 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY