TECHNETIUM TC-99M DISOFENIN

First approved in 1973

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H26N2O5.Tc
Molecular Weight	449.3157
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TECHNETIUM TC-99M DISOFENIN

Structure Search

SMILES

[99Tc].CC(C)C1=CC=CC(C(C)C)=C1NC(=O)CN(CC(O)=O)CC(O)=O

InChI

InChIKey=JNJYQGLIZTUSCW-IEOVAKBOSA-N

InChI=1S/C18H26N2O5.Tc/c1-11(2)13-6-5-7-14(12(3)4)18(13)19-15(21)8-20(9-16(22)23)10-17(24)25;/h5-7,11-12H,8-10H2,1-4H3,(H,19,21)(H,22,23)(H,24,25);/i;1+1

HIDE SMILES / InChI

Molecular Formula	Tc
Molecular Weight	98.9063
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H26N2O5
Molecular Weight	350.4094
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.hindawi.com/journals/stni/2014/839369/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
bone problems 43 Sources: https://www.drugs.com/cons/osteolite.html	Diagnostic	Approved 8429	OSTEOLITE Approved Use Unknown Launch Date 1977
osteogenesis 43 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018035s032lbl.pdf	Diagnostic	Approved 8429	DRAXIMAGE MDP-10 Approved Use MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date 1978

PubMed

Title	Date	PubMed
Future of low specific activity molybdenum-99/technetium-99m generator.	2012 Oct	22642420

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:59:16 GMT 2023` Edited by `admin` on `Fri Dec 15 15:59:16 GMT 2023`
Record UNII	QTJ2VIW97T
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

TECHNETIUM TC-99M DISOFENIN

Common Name

English

Technetium tc 99m disofenin [WHO-DD]

Common Name

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TECHNETIUM TC 99M DISOFENIN [USP IMPURITY]

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TECHNETIUM TC 99M DISOFENIN

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TECHNETIUM TC 99M DISOFENIN [VANDF]

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Classification Tree Code System Code

WHO-ATC

V09DA01