NICLOSAMIDE-OLAMINE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H8Cl2N2O4.C2H7NO
Molecular Weight	388.203
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCO.OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O

InChI

InChIKey=XYCDHXSQODHSLG-UHFFFAOYSA-N

InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2

HIDE SMILES / InChI

Molecular Formula	C13H8Cl2N2O4
Molecular Weight	327.12
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C2H7NO
Molecular Weight	61.0831
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.drugbank.ca/drugs/DB06803
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/mmx/niclosamide.html

Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism. Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA. Niclosamide is used for the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis. Niclosamide was marketed under the trade name Niclocide, now discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Staphylococcus aureus 70 Target ID: CHEMBL352 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25897961	Inhibitor 8504
Enterococcus faecium 6 Target ID: CHEMBL357 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25897961	Inhibitor 8504
Cytochrome P450 1A2 73 Target ID: CHEMBL3356 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11124226	Inhibitor 8504	2.7 µM [Ki]
Hymenolepis nana 3 Target ID: CHEMBL612450 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6841958	Inhibitor 8504
Taenia saginata 3 Target ID: Taenia saginata Sources: https://www.ncbi.nlm.nih.gov/pubmed/3425963	Inhibitor 8504
MCF7 22 Target ID: CHEMBL387 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27545321	Inhibitor 8504	45.0 µM [IC50]
DNA 282 Target ID: CHEMBL2366043 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12392939	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Diphyllobothriasis 3 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8583	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 1982
Hymenolepiasis 3 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8583	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 1982
Taeniasis 3 Sources: https://www.drugs.com/cons/niclosamide.html	Curative	Approved 8583	NICLOCIDE Approved Use Diphyllobothriasis (treatment)—Niclosamide is indicated in the treatment of diphyllobothriasis caused by Diphyllobothrium latum (broad or fish tapeworm). Hymenolepiasis (treatment)—Niclosamide is indicated in the treatment of hymenolepiasis caused by Hymenolepis nana (dwarf tapeworm) and [H. diminuta (rat tapeworm)] . Taeniasis (treatment)—Niclosamide is indicated in the treatment of taeniasis caused by Taenia saginata (beef tapeworm) and [T. solium (pork tapeworm)] . [Dipylidiasis (treatment)]—Niclosamide is used in the treatment of dipylidiasis caused by Dipylidium caninum (dog and cat tapeworm). Launch Date 1982

C_max

Value	Dose	Co-administered	Analyte	Population
0.665 μg/mL EXPERIMENT https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e14536	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:		NICLOSAMIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	DLT: Nausea, Vomiting... Dose limiting toxicities: Nausea (grade 3, 2 patients) Vomiting (grade 3, 2 patients) Diarrhea (grade 3, 2 patients) Colitis (grade 3, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/29856824

AEs

AE	Significance	Dose	Population
Colitis	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Diarrhea	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Nausea	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29856824
Vomiting	grade 3, 2 patients DLT	1000 mg 3 times / day steady, oral Dose: 1000 mg, 3 times / day Route: oral Route: steady Dose: 1000 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/29856824	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/29856824

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946	inhibitor 2438 activator 23 substrate 1193	substrate 1388

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153	CYP1A1 389 CYP1A2 1197 CYP1B1 104 CYP2B6 776 CYP2C8 810 CYP2C19 1119 CYP2E1 729 CYP3A5 446 UGT1A1 479 UGT1A3 470 UGT1A4 399 UGT1A6 343 UGT1A7 249 UGT1A8 323 UGT1A9 423 UGT1A10 331 UGT2B4 278 UGT2B7 456 UGT2B15 236 UGT2B17 237

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes [Ki 2.7 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes [Ki 6 uM]
CYP2C9 2497	activator 342 Sources: https://pubmed.ncbi.nlm.nih.gov/11124226/	yes

Drug as victim

Target	Modality	Activity
CYP1B1 104	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2B6 776	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C19 1119	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C8 810	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2C9 1193	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2D6 1388	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP2E1 729	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
CYP3A5 446	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 3.0	no
UGT1A4 399	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT1A6 343	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B15 236	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B17 237	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
UGT2B4 278	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	no
CYP1A1 389	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 6.0	yes
CYP1A2 1197	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 6.0	yes
UGT1A1 479	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A10 331	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A3 470	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A7 249	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A8 323	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT1A9 423	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes
UGT2B7 456	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/26068521/ Page: 7.0	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-0772	http://www.3bsc.com/index/pro_info.php?id=20128
AA Blocks	AA0035B8	http://www.aablocks.com/goods/Goods/detail?id=AA0035B8
Aaron Chemicals	AR003630	http://www.aaronchem.com/50-65-7
abcr GmbH	AB372324	http://www.abcr.com/shop/en/AB372324
AbMole Bioscience	M2055	http://www.abmole.com/products/niclosamide.html
Acadechem	ACDS-028814	http://www.acadechemical.com/product/103513
Achemtek	0104-015424	http://www.achemtek.com/50-65-7
Achemtek	1ST20493	http://achemtek.com/50-65-7-2
Acros Organics	AC461840250	https://www.fishersci.com/shop/products/niclosamide-97-acros-organics-1/AC461840250
Acros Organics	AC461841000	https://www.fishersci.com/shop/products/niclosamide-97-acros-organics/AC461841000
AHH Chemical co.,ltd	API-1745	http://www.ahhchemical.com/product/API-1745.html
AK Scientific, Inc. (AKSCI)	I012	http://www.aksci.com/item_detail.php?cat=I012
Alfa Chemistry	AP50657	https://reagents.alfa-chemistry.com/product/niclosamide-cas-50-65-7-cas-50-65-7-12166.html
Angene	AGN-PC-08WHBK	http://www.angenechemical.com/productshow/AGN-PC-08WHBK.html
ApexBio Technology	B2283	http://www.apexbt.com/niclosamide.html
Ark Pharm	AK173020	http://www.arkpharminc.com/products/50-65-7.html
Aurora Fine Chemicals LLC	K04.832.702	http://online.aurorafinechemicals.com/info?ID=K04.832.702
Aurum Pharmatech LLC	T7903	http://www.Aurumpharmatech.com/Product/ProductDetails/T7903
AvaChem Scientific	6587	https://www.avachem.com/productSearch.asp?6587
BioChemPartner	BCP22958	http://www.biochempartner.com/50-65-7-BCP22958
BioCrick	BCC5081	http://www.biocrick.com/Niclosamide-BCC5081.html
BioSynth	Q-201469	https://www.biosynth.com/en/products/life-science/enzyme-substrates-reagents/products/Q-201469.html
Chem Scene	CS-2618	http://www.chemscene.com/50-65-7.html
Chemenu	CM110596	http://www.chemenu.com/products/CM110596
ChemMol	49409397	http://www.chemmol.com/chemmol/49409397.html
ChemMol	99097726	http://www.chemmol.com/chemmol/99097726.html
Chemspace	CSSB00000764091	https://chem-space.com/CSSB00000764091
Debye Scientific	DB-051812	http://www.debyesci.com/cas_50-65-7.html
EMD Biosciences	481909	http://www.emdbiosciences.com/product/481909
EMD Millipore	481909	http://www.emdbiosciences.com/product/481909
Enamine	Z57902203	https://www.enaminestore.com/catalog/Z57902203
eNovation Chemicals	D672942	https://www.enovationchem.com/ProductDetails.asp?ProductID=D672942
eNovation Chemicals	D765674	https://www.enovationchem.com/ProductDetails.asp?ProductID=D765674
Finetech	FT-0603220	http://www.finetechnology-ind.com/prod/detail/pub/50-65-7.html
Glentham Life Sciences	GA5338	http://www.glentham.com/products/product/GA5338/
Hello Bio	HB1435	https://www.hellobio.com/niclosamide.html
iChemical	EBD38831	http://www.ichemical.com/chemicals/cas-50-65-7
LGC Standards	DRE-A15510000AL-100	https://www.lgcstandards.com/US/en/p/DRE-A15510000AL-100
LGC Standards	DRE-C15510000	https://www.lgcstandards.com/US/en/p/DRE-C15510000
LGC Standards	LGCFOR0361.00	https://www.lgcstandards.com/US/en/p/LGCFOR0361.00
LGC Standards	MM0361.00	https://www.lgcstandards.com/US/en/p/MM0361.00
Matrix Scientific	203850	https://www.matrixscientific.com/203850.html
mcule	MCULE-9985514311	https://mcule.com/MCULE-9985514311/
MedChem Express	HY-B0497	https://www.medchemexpress.com/Niclosamide.html
Selleck Chemicals	S3030	http://www.selleckchem.com/products/niclosamide-niclocide.html
Sigma-Aldrich	N0560000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/n0560000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	N3510_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/n3510?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S013157	http://www.sinfoobiotech.com/product/1016555
Smolecule	S548510	http://www.smolecule.com/products/s548510
Speranza Chemical Co., Ltd.	C057	http://www.speranzachem.com/products-50-65-7.html
Synblock Inc	SB19414	http://www.synblock.com/product/50-65-7.html
THE BioTek	bt-287919	https://www.thebiotek.com/product/inhibitors/bt-287919
Tocris	4079	https://www.tocris.com/products/niclosamide_4079
VladaChem	VL264556-100G	https://www.vladachem.com/product.php?products=50-65-7
Yuhao Chemical	HL1041	http://www.chemyuhao.com/50-65-7.html

PubMed

Title	Date	PubMed
Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.	2009-11-13	19426989
Halogenated pesticide transformation by a laccase-mediator system.	2009-10	19695672
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.	2009-08	19225094
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.	2009-07-14	19597541
Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivities.	2009-06-06	18782722
Diphyllobothrium latum identified by capsule endoscopy--an unusual cause of iron-deficiency anemia.	2009-06	19565041
The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.	2009-03-01	19160421
Spatial epidemiology in zoonotic parasitic diseases: insights gained at the 1st International Symposium on Geospatial Health in Lijiang, China, 2007.	2009-02-04	19193214
A retrospective analysis of prevalence of gastrointestinal parasites among school children in the Palajunoj Valley of Guatemala.	2009-02	19248646
Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures.	2009	19172178
Potential of some monoterpenoids and their new N-methyl carbamate derivatives against Schistosomiasis snail vector, Biomphalaria alexandrina.	2008-11	17692915
Harnessing the wealth of Chinese scientific literature: schistosomiasis research and control in China.	2008-09-30	18826598
[Snail control by using soil pasting mixed with niclosamide].	2008-08	19115619
Efficacy of temperature, and two commonly used molluscicides and fertilizers on Fasciola gigantica eggs.	2008-08	18853633
A novel molluscicidal formulation of niclosamide.	2008-07	18454287
Hymenolepis diminuta: mitochondrial transhydrogenase as an additional site for anaerobic phosphorylation.	2008-05	18262524
[Human infection due to Bertiella sp (cestode: Anoplocephalidae) in a man originating from Yemen in Algeria].	2008-04	18543702
In vitro trypanocidal activity of the anti-helminthic drug niclosamide.	2008-04	18226810
Voltammetric Behavior of o-Nitrophenol and Damage to DNA.	2008-03	19325751
Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide.	2008-01	17962058
Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial.	2008	18923706
Effect of niclosamide on the tegumental surface of Haplorchis taichui using scanning electron microscopy.	2007-12	17588285
[Study on molluscicidal effect of chlorosalicylicamide].	2007-10	18441997
Taeniasis and its socio-economic implication in Awassa town and its surroundings, Southern Ethiopia.	2007-10	18085135
Sympatric occurrence of Taenia solium, T. saginata, and T. asiatica, Thailand.	2007-09	18252126
Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian Cameroon.	2007-09	17716430
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.	2007-08-23	17663539
A studies on chemical control of S. mansoni intermediate host.	2007-08-01	19070141
Large water management projects and schistosomiasis control, Dongting Lake region, China.	2007-07	18214167
Cream formulations protecting against cercarial dermatitis by Trichobilharzia.	2007-06	17252275
5(6)-Carboxyfluorescein diacetate as an indicator of Caenorhabditis elegans viability for the development of an in vitro anthelmintic drug assay.	2007-03-30	19071538
[Study on molluscicidal effect of the extracts from sarcotesta of Ginkgo biloba].	2007-02-28	17639699
Lower-rim substituted calixarenes and their applications.	2007	17611612
Influence of certain fertilizers on the activity of some molluscicides against Biomphalaria alexandrina and Lymnaea natalensis snails.	2006-12	17153706
[Cleaning and molluscicide treatment for schistosomiasis control].	2006-10-14	17037230
[A study on the effect of Oncomelania hupensis hupensiss killed with niclosamide in China].	2006-08	17175588
Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.	2006-08	16832819
[Synergic effects of synthesis arecoline in combination with snail-killing drugs niclosamide].	2006-07	17097004
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.	2006-06-09	16789813
Field trials of low dose Bayluscide on snail hosts of schistosome and selected non-target organisms in sahelian Cameroon.	2006-06	16951803
Potential antivirals and antiviral strategies against SARS coronavirus infections.	2006-04	16597209
Catalysis of NADH-->NADP+ transhydrogenation by adult Hymenolepis diminuta mitochondria.	2006-02	16328369
[Case report: taeniasis, is it a cause of psychiatric and neural symptoms?].	2006	17160849
Role of chemotherapy of taeniasis in prevention of neurocysticercosis.	2006	16356763
Impact of certain plants and synthetic molluscicides on some fresh water snails and fish.	2005-12	16333905
Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.	2005-11-04	16198076
Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic.	2005-09-02	16146345
Taeniasis and cysticercosis in housemaids working in affluent neighborhoods in Lima, Peru.	2005-09	16172470
[Treatment of intestinal helminthiasis with albendazole].	2005-06-30	15984617
Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout.	2005-06-29	15969516

Patents

Sample Use Guides

In Vivo Use Guide

Adults—2 grams as a single dose. Treatment may be repeated in seven days if needed.

Route of Administration: Oral

In Vitro Use Guide

Niclosamide (0.2 ug/ml) was effective against Diplozoon paradoxum after an exposure of 90 min and 45 min in vitro.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:53:00 GMT 2025` Edited by `admin` on `Mon Mar 31 19:53:00 GMT 2025`
Record UNII	QT8YUD1Z0W
Record Status	`Validated (UNII)`
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Name

Type

Language

NICLOSAMIDE-OLAMINE

Common Name

English

NICLOSAMIDE ETHANOLAMINE SALT

Preferred Name

English

BAYLUSCIDE

Brand Name

English

UCCMALUSCIDE

Brand Name

English

M-73

Code

English

BENZAMIDE, 5-CHLORO-N-(2-CHLORO-4-NITROPHENYL)-2-HYDROXY-, COMPD. WITH 2-AMINOETHANOL (1:1)

Systematic Name

English

NICLOSAMIDE-OLAMINE [HSDB]

Common Name

English

NICLOSAMIDE-OLAMINE [ISO]

Common Name

English

CLONITRALIDE

Common Name

English

NICLOSAMIDE ETHANOLAMINE SALT [MI]

Common Name

English

BAY-6076

Code

English

Code System Code Type Description

SMS_ID

300000025137