Ulviprubart

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NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:03:35 GMT 2025` Edited by `admin` on `Wed Apr 02 09:03:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	QT44II3WZP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ulviprubart

Official Name

English

ABC-008

Preferred Name

English

ULVIPRUBART [USAN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens KLRG1(killer cell lectin like receptor G1, MAFA, CLEC15A)], humanized monoclonal antibody

Common Name

English

gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV1-8*01 (81.6%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), C

Common Name

English

ANTI-KLRG1 (AFUCOSYLATED, HUMANIZED IGG1)

Common Name

English

ABC008

Code

English

Immunoglobulin G1, anti-(human killer cell lectin-like receptor subfamily G member 1) (human-Mus musculus monoclonal ABC008 ?1-chain), disulfide with human-Mus musculus monoclonal ABC008 ?-chain, dime

Common Name

English

ulviprubart [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

681119

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C190482

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

PRIMARY

INN

12298

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

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CAS

2569434-60-0

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

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SMS_ID

300000041969

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

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USAN

LM-252

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

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FDA UNII

QT44II3WZP

Created by admin on Wed Apr 02 09:03:35 GMT 2025 , Edited by admin on Wed Apr 02 09:03:35 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_219
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_94
3_139	3_199
4_23	4_94
4_139	4_199
1_222	3_219
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_299
N	2_299

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL