14-(R)-Hydroxyclarithromycin

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C38H69NO14
Molecular Weight	763.9528
Optical Activity	UNSPECIFIED
Defined Stereocenters	19 / 19
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 14-(R)-Hydroxyclarithromycin

Structure Search

SMILES

CO[C@]1(C)C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@H](OC(=O)[C@@H]2C)[C@@H](C)O)OC)O[C@@H](C)[C@@H]1O

InChI

InChIKey=BLPFDXNVUDZBII-KTDRUCRASA-N

InChI=1S/C38H69NO14/c1-18-16-37(9,48-14)32(53-35-28(42)25(39(11)12)15-19(2)49-35)21(4)29(51-26-17-36(8,47-13)31(44)24(7)50-26)22(5)34(45)52-33(23(6)40)38(10,46)30(43)20(3)27(18)41/h18-26,28-33,35,40,42-44,46H,15-17H2,1-14H3/t18-,19-,20+,21+,22-,23-,24+,25+,26+,28-,29+,30-,31+,32-,33-,35+,36-,37-,38+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C38H69NO14
Molecular Weight	763.9528
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	19 / 19
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 20:30:37 GMT 2025` Edited by `admin` on `Wed Apr 02 20:30:37 GMT 2025`
Record UNII	QS9JUX3AKY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

14-(R)-Hydroxyclarithromycin

Common Name

English

(14R)-14-Hydroxyclarithromycin

Preferred Name

English

(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetra hydro-2H-pyran-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexa

Systematic Name

English

Erythromycin, 14-hydroxy-6-O-methyl-, (14R)-

Common Name

English

(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dion

Systematic Name

English

Code System Code Type Description

FDA UNII

QS9JUX3AKY

Created by admin on Wed Apr 02 20:30:37 GMT 2025 , Edited by admin on Wed Apr 02 20:30:37 GMT 2025

PRIMARY

PUBCHEM

13921565

Created by admin on Wed Apr 02 20:30:37 GMT 2025 , Edited by admin on Wed Apr 02 20:30:37 GMT 2025

PRIMARY

CAS

116836-41-0

Created by admin on Wed Apr 02 20:30:37 GMT 2025 , Edited by admin on Wed Apr 02 20:30:37 GMT 2025

PRIMARY

Related Record Type Details


					H1250JIK0A

CLARITHROMYCIN

PARENT -> METABOLITE

Amount:

Name	Property Type	Parameters
MIC	BIOLOGICAL	PATHOGEN: S. PYOGENES, S. PNEUMONIAE, H. PYLORI SUSCEPTIBILITY: RESISTANT
Biological Half-life	PHARMACOKINETIC	14-OH-CLARITHROMYCIN
MIC	BIOLOGICAL	PATHOGEN: S. AUREUS SUSCEPTIBILITY: RESISTANT
MIC	BIOLOGICAL	PATHOGEN: H. INFLUENZAE SUSCEPTIBILITY: SUSCEPTIBLE
MIC	BIOLOGICAL	SUSCEPTIBILITY: SUSCEPTIBLE PATHOGEN: S. PYOGENES, S. PNEUMONIAE, H. PYLORI
MIC	BIOLOGICAL	SUSCEPTIBILITY: INTERMEDIATE PATHOGEN: S. AUREUS
MIC	BIOLOGICAL	PATHOGEN: H. INFLUENZAE SUSCEPTIBILITY: INTERMEDIATE
Biological Half-life	PHARMACOKINETIC
MIC	BIOLOGICAL	PATHOGEN: S. AUREUS SUSCEPTIBILITY: SUSCEPTIBLE
MIC	BIOLOGICAL	PATHOGEN: S. PYOGENES, S. PNEUMONIAE SUSCEPTIBILITY: INTERMEDIATE
MIC	BIOLOGICAL	SUSCEPTIBILITY: RESISTANT PATHOGEN: H. INFLUENZAE
Tmax	PHARMACOKINETIC	FORMULATION: IMMEDIATE RELEASE
Tmax	PHARMACOKINETIC	FORMULATION: EXTENDED RELEASE
ORAL BIOAVAILABILITY	PHARMACOKINETIC