PAMREVLUMAB

Investigational

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	QS5F6VTS0O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IMMUNOGLOBULIN G1, ANTI-(HUMAN CONNECTIVE TISSUE GROWTH FACTOR) (HUMAN MONOCLONAL FG-3019 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL FG-3019 .KAPPA.-CHAIN, DIMER

Preferred Name

English

PAMREVLUMAB

Official Name

English

PAMREVLUMAB [USAN]

Common Name

English

pamrevlumab [INN]

Common Name

English

FG-3019

Code

English

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Classification Tree

Code System

Code

Designated

FDA ORPHAN DRUG

680319

Designated

FDA ORPHAN DRUG

351211

Designated

FDA ORPHAN DRUG

581617

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Code System

Code

Type

Description

DRUG BANK

DB14952

PRIMARY

INN

10060

PRIMARY

SMS_ID

100000183613

PRIMARY

USAN

DE-89

PRIMARY

ChEMBL

CHEMBL2109377

PRIMARY

Showing 1 to 5 of 8 entries

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_95
1_147	1_203
1_264	1_324
1_370	1_428
2_22	2_95

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Linkage Type	Residue Index
CROSSLINK	1_109	2_109

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					72GT7X86WW

CONNECTIVE TISSUE GROWTH FACTOR

TARGET -> INHIBITOR

Related Record Type Details


					QS5F6VTS0O

PAMREVLUMAB

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_109] [2_109]	C	CYSTINE	48TCX9A1VT
AMINO ACID SUBSTITUTION	[1_109] [2_109]	C	L-CYSTEINYL GLYCINE L-CYSTEINE DISULFIDE	6EWB1CV9U2
AMINO ACID SUBSTITUTION	[1_109] [2_109]	C	CYSTEINE-GLUTATHIONE DISULFIDE	89TEL00G6V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6380H9862O2000N1714S48
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 144000 Da (average)