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Nerolidol (aka peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. The aroma of nerolidol is woody and reminiscent of fresh bark. It is used as a flavoring agent and in perfumery. It is also used in non-cosmetic products such as detergents and cleansers. Additionally, it is known for several biological activities including antioxidant, anti-fungal, anticancer, and antimicrobial activities.

CNS Activity

Curator's Comment:: referenced study was conducted in mouse

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Nerolidol effects on mitochondrial and cellular energetics.
2012 Mar
Patents

Sample Use Guides

The essential oils Carvone, Eugenol, Geraniol, and Nerolidol are included in the viricidal spray AV2 in equal volumes diluted 50% in olive oil. The spray is topically administered to the cervix while the subject is in the lithotomic position and fitted with a speculum. Two pumps are administered with each pump delivering 100 micro-L of the solution.
Route of Administration: Vaginal
HepG2 cells were cultured in minimum essential medium (MEM) Eagle (with 2 mM L-glutamine and Earle's buffered saline solution (BSS) adjusted to contain 1.5 g/L sodium bicarbonate, 0.1 mM nonessential amino acids, and 1 mM sodium pyruvate), containing 10% fetal bovine serum. Cells were seeded in a 24-well plate and allowed to attach and recover for 1 day prior to drug treatment. Nerolidol was added at concentrations of 1.2 and 2.4 microM for proliferation assays and 10, 50, and 100 microM for cell viability assays. Cells were cultured for up o 3 days without media change or drug replenishment. At various time points, cells were washed, fixed and stained with sulforhodamine B to determine cell proliferation. Cytotoxicity of nerolidol was also evaluated through MTT assay. Nerolidol was toxic to HepG2 cells after 24 hours with a very strong inhibition of cell proliferation present even at the lowest concentrations tested (10 microM).
Substance Class Mixture
Created
by admin
on Sat Jun 26 18:52:24 UTC 2021
Edited
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on Sat Jun 26 18:52:24 UTC 2021
Record UNII
QR6IP857S6
Record Status Validated (UNII)
Record Version
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Name Type Language
NEROLIDOL
FCC   FHFI   INCI   MI  
INCI  
Official Name English
3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL
Common Name English
FEMA NO. 2772
Common Name English
NEROLIDOL [FCC]
Common Name English
NEROLIDOL [MI]
Common Name English
NERODILOL
Common Name English
NEROLIDOL [FHFI]
Common Name English
1,6,10-DODECATRIEN-3-OL, 3,7,11-TRIMETHYL-
Common Name English
NEROLIDOL [INCI]
Common Name English
FCI-119B
Code English
NEROLIDOL, (+/-)-
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 128911
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
CFR 21 CFR 172.515
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
JECFA EVALUATION NEROLIDOL
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
Code System Code Type Description
FDA UNII
QR6IP857S6
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
MERCK INDEX
M7831
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
NEROLIDOL
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
ECHA (EC/EINECS)
230-597-5
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
RXCUI
2371699
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
EPA CompTox
7212-44-4
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
CAS
7212-44-4
Created by admin on Sat Jun 26 18:52:24 UTC 2021 , Edited by admin on Sat Jun 26 18:52:24 UTC 2021
PRIMARY
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Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Definition References