Macitegtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 19:49:04 GMT 2025` Edited by `admin` on `Wed Apr 02 19:49:04 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	cd4/cd8 enriched t cells
Record UNII	QQ55NF53RR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

autologous CD4/CD8 enriched T lymphocytes derived from peripheral blood mononuclear cells (PBMC) of patients by leukapheresis, transduced with a selfinactivating, non-replicating lentiviral vector encoding a a chimeric antigen receptor (CAR) targeting th

Preferred Name

English

Macitegtagene Autoleucel

Official Name

English

macitegtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C211716

Created by admin on Wed Apr 02 19:49:04 GMT 2025 , Edited by admin on Wed Apr 02 19:49:04 GMT 2025

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FDA UNII

QQ55NF53RR

Created by admin on Wed Apr 02 19:49:04 GMT 2025 , Edited by admin on Wed Apr 02 19:49:04 GMT 2025

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INN

13281

Created by admin on Wed Apr 02 19:49:04 GMT 2025 , Edited by admin on Wed Apr 02 19:49:04 GMT 2025

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Related Record Type Details


					602I13CWRT

INTERCELLULAR ADHESION MOLECULE 1

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					QQ55NF53RR

Macitegtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION	Macitegtagene autoleucel lentiviral vector	ELY7WDV57K
CULTURE	EXPANSION	BIOLOGICAL	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CULTURE	ACTIVATOR		T CELL TRANSACT, HUMAN	YG578HEY4V
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN	Macitegtagene autoleucel expressed human somatostatin receptor type 2	W4VZJ87D9E
INSERTED GENE EXPRESSION VECTOR	Macitegtagene autoleucel transgene insert	LV296BSH6N
VECTOR EXPRESSED PROTEIN	Macitegtagene autoleucel expressed chimeric antigen receptor (CAR) targeting the intercellular adhesion molecule-1 (ICAM-1)	C5Z3F98QQV
VECTOR EXPRESSED PROTEIN	Macitegtagene autoleucel expressed preprotein (CAR targeting ICAM-1fused to human somatostatin receptor type 2 (SSTR2) separates by P2A peptide)	Q6ND6YVF2C