Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H32FN3O4 |
| Molecular Weight | 433.5163 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)C4=C1C=CC(F)=C4
InChI
InChIKey=AGMOFKKOVMRGAK-UHFFFAOYSA-N
InChI=1S/C23H32FN3O4/c1-22(2)18-4-3-17(24)13-19(18)27(20(22)28)21(29)25-14-16-5-9-26(10-6-16)15-23(30)7-11-31-12-8-23/h3-4,13,16,30H,5-12,14-15H2,1-2H3,(H,25,29)
| Molecular Formula | C23H32FN3O4 |
| Molecular Weight | 433.5163 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
PF-03382792 is an oxindole derivative. PF-03382792 is highly potent and selective 5-HT4 partial agonist. It has excellent brain penetration properties. PF-03382792 increased acetylcholine release in the rat prefrontal cortex. It have been reported to reverse learning deficits induced by cholinergic agents. A safety assessment of this compound revealed large therapeutic margins between efficacious concentrations and safety findings. PF-03382792 reached human Phase I clinical trials but future development was discontinued.
CNS Activity
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:59:19 GMT 2025
by
admin
on
Mon Mar 31 20:59:19 GMT 2025
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| Record UNII |
QPE81T4KH0
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| Record Status |
Validated (UNII)
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| Record Version |
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QPE81T4KH0
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DB12949
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1400811-63-3
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71451950
Created by
admin on Mon Mar 31 20:59:19 GMT 2025 , Edited by admin on Mon Mar 31 20:59:19 GMT 2025
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ACTIVE MOIETY |
