1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)ETHANE

O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

InChIKey=GBLIGNUYGOFIKS-UHFFFAOYSA-N

InChI=1S/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons.	2003 Feb	12643037
Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.	2005 Sep 2	16053917
A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo.	2007 Oct	17622580
Antimetastatic activities and mechanisms of bisdioxopiperazine compounds.	2010 Sep	20950258

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:15:06 GMT 2023` Edited by `admin` on `Fri Dec 15 19:15:06 GMT 2023`
Record UNII	QML51S42CD
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)ETHANE

Systematic Name

English

2,6-PIPERAZINEDIONE, 4,4'-(1,2-ETHANEDIYL)BIS-

Systematic Name

English

ANTIMET

Common Name

English

2,6-PIPERAZINEDIONE, 4,4'-ETHYLENEDI-

Systematic Name

English

NSC-129942

Code

English

GLYCINE, N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)-, N,N:N',N'-DIIMIDE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID40164579