1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)ETHANE

O=C1CN(CCN2CC(=O)NC(=O)C2)CC(=O)N1

InChIKey=GBLIGNUYGOFIKS-UHFFFAOYSA-N

InChI=1S/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Antimetastatic activities and mechanisms of bisdioxopiperazine compounds.	2010-09	20950258
A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo.	2007-10	17622580
Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.	2005-09-02	16053917
Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha.	2003-05	12695544
Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons.	2003-02	12643037

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:40:12 GMT 2025` Edited by `admin` on `Mon Mar 31 19:40:12 GMT 2025`
Record UNII	QML51S42CD
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)ETHANE

Systematic Name

English

NSC-129942

Preferred Name

English

2,6-PIPERAZINEDIONE, 4,4'-(1,2-ETHANEDIYL)BIS-

Systematic Name

English

ANTIMET

Common Name

English

2,6-PIPERAZINEDIONE, 4,4'-ETHYLENEDI-

Systematic Name

English

GLYCINE, N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)-, N,N:N',N'-DIIMIDE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID40164579