TINOSTAMUSTINE HYDROCHLORIDE

Cl.CN1C(CCCCCCC(=O)NO)=NC2=C1C=CC(=C2)N(CCCl)CCCl

InChIKey=DWGQFQRWFYIINU-UHFFFAOYSA-N

InChI=1S/C19H28Cl2N4O2.ClH/c1-24-17-9-8-15(25(12-10-20)13-11-21)14-16(17)22-18(24)6-4-2-3-5-7-19(26)23-27;/h8-9,14,27H,2-7,10-13H2,1H3,(H,23,26);1H

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Histone deacetylase 6 27 Target ID: CHEMBL1865 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25980817	Inhibitor 8297	6.0 nM [IC50]
Histone deacetylase 1 51 Target ID: CHEMBL325 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25980817	Inhibitor 8297	9.0 nM [IC50]
Histone deacetylase 2 37 Target ID: CHEMBL1937 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25980817	Inhibitor 8297	9.0 nM [IC50]
Histone deacetylase 3 35 Target ID: CHEMBL1829 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25980817	Inhibitor 8297	25.0 nM [IC50]

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:51:28 UTC 2023` Edited by `admin` on `Sat Dec 16 14:51:28 UTC 2023`
Record UNII	QK4ZBS4FPO
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

TINOSTAMUSTINE HYDROCHLORIDE

Common Name

English

1H-BENZIMIDAZOLE-2-HEPTANAMIDE, 5-(BIS(2-CHLOROETHYL)AMINO)-N-HYDROXY-1-METHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

2-DESBUTYLCARBOXY-2-(N-HYDROXYHEPTANAMINO) BENDAMUSTINE HYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

634018