U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 15:39:53 GMT 2023
Edited
by admin
on Sat Dec 16 15:39:53 GMT 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials State LIVE ATTENUATED GENETICALLY MODIFIED
Organism Family Adenoviridae
Organism Genus Mastadenovirus
Organism Species human mastadenovirus c
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name TYPE 5 (H-101)
Part WHOLE
Record UNII
QH36X20ODG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
H-101
Code English
GENETICALLY-MODIFIED ONCOLYTIC TYPE 5 ADENOVIRUS WHICH SELECTIVELY REPLICATES IN TUMOR CELLS CONTAINING DYSFUNCTIONAL P53 GENE (H101)
Common Name English
H101
Code English
ONCORINE
Brand Name English
Code System Code Type Description
CAS
1802358-15-1
Created by admin on Sat Dec 16 15:39:53 GMT 2023 , Edited by admin on Sat Dec 16 15:39:53 GMT 2023
PRIMARY
FDA UNII
QH36X20ODG
Created by admin on Sat Dec 16 15:39:53 GMT 2023 , Edited by admin on Sat Dec 16 15:39:53 GMT 2023
PRIMARY
NCI_THESAURUS
C107504
Created by admin on Sat Dec 16 15:39:53 GMT 2023 , Edited by admin on Sat Dec 16 15:39:53 GMT 2023
PRIMARY NCIT
Related Record Type Details
TARGET -> INHIBITOR
INHIBITS TUMORS THAT DO NOT EXPRESS P53
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
PROTEIN NOT EXPRESSED (GENE DISRUPTION) EARLY E3 18.5 KDA GLYCOPROTEIN D44QHG1RMM
PROTEIN NOT EXPRESSED (GENE DISRUPTION) UNSPECIFIED SUBSTANCE
aac35376
(not in database)
GENE DELETION ADENOVIRUS SEROTYPE 5 E1B 55 KD GENE NWT3SVP3ZT