GNE-149

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H33F4N3O
Molecular Weight	503.5747
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1CC2=C(NC3=C2C=CC=C3)[C@H](N1CC(C)(C)F)C4=C(F)C=C(OC5CN(CCCF)C5)C=C4F

InChI

InChIKey=BKHIBYHLBQEIQK-XGCWNURASA-N

InChI=1S/C28H33F4N3O/c1-17-11-21-20-7-4-5-8-24(20)33-26(21)27(35(17)16-28(2,3)32)25-22(30)12-18(13-23(25)31)36-19-14-34(15-19)10-6-9-29/h4-5,7-8,12-13,17,19,27,33H,6,9-11,14-16H2,1-3H3/t17-,27-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H33F4N3O
Molecular Weight	503.5747
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 10:40:59 GMT 2025` Edited by `admin` on `Wed Apr 02 10:40:59 GMT 2025`
Record UNII	QFR2PB365C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GNE-149

Code

English

GNE149

Preferred Name

English

(1R,3R)-1-[2,6-Difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]oxy]phenyl]-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indole

Systematic Name

English

1H-Pyrido[3,4-b]indole, 1-[2,6-difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]oxy]phenyl]-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-, (1R,3R)-

Systematic Name

English

3-{3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl]phenoxy}-1-(3-fluoropropyl)azetidine

Systematic Name

English

Code System Code Type Description

PUBCHEM

121410669

Created by admin on Wed Apr 02 10:40:59 GMT 2025 , Edited by admin on Wed Apr 02 10:40:59 GMT 2025

PRIMARY

CAS

1953132-75-6

Created by admin on Wed Apr 02 10:40:59 GMT 2025 , Edited by admin on Wed Apr 02 10:40:59 GMT 2025

PRIMARY

FDA UNII

QFR2PB365C

Created by admin on Wed Apr 02 10:40:59 GMT 2025 , Edited by admin on Wed Apr 02 10:40:59 GMT 2025

PRIMARY

Related Record Type Details


					SIDP85PFD6

ESTROGEN RECEPTOR

TARGET->INHIBITOR, RECEPTOR DEGRADER

Comments:

MCF-7 cells SERD

Qualification:

IC50

Amount: