Ersodetug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:03:59 UTC 2023` Edited by `admin` on `Sat Dec 16 14:03:59 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	QD87BSP58N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ersodetug

Official Name

English

XOMA-358

Code

English

immunoglobulin G2-kappa, anti-[Homo sapiens INSR (insulin receptor)], Homo sapiens monoclonal antibody, allosteric

Common Name

English

gamma2 heavy chain Homo sapiens (1-444) [VH(Homo sapiens IGHV3-20*01 (98.0%) -(IGHD)-IGHJ6*01 (93.8%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG2*02 (100%), G2m23 CH2 M45.1 (CH1 (119-216), hinge 1-12 (217-228), CH2 M45.1 (279) (2

Common Name

English

RZ358

Common Name

English

Immunoglobulin G2, anti-(human insulin receptor) (human monoclonal RZ358 γ2-chain), disulfide with human monoclonal RZ358 κ-chain, dimer

Common Name

English

ersodetug [INN]

Common Name

English

RZ-358

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

430714

Created by admin on Sat Dec 16 14:04:00 UTC 2023 , Edited by admin on Sat Dec 16 14:04:00 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C199043

Created by admin on Sat Dec 16 14:04:00 UTC 2023 , Edited by admin on Sat Dec 16 14:04:00 UTC 2023

PRIMARY

INN

12218

Created by admin on Sat Dec 16 14:04:00 UTC 2023 , Edited by admin on Sat Dec 16 14:04:00 UTC 2023

PRIMARY

CAS

2410976-61-1

Created by admin on Sat Dec 16 14:04:00 UTC 2023 , Edited by admin on Sat Dec 16 14:04:00 UTC 2023

PRIMARY

FDA UNII

QD87BSP58N

Created by admin on Sat Dec 16 14:04:00 UTC 2023 , Edited by admin on Sat Dec 16 14:04:00 UTC 2023

PRIMARY

From	To
1_22	1_96
1_132	3_219
1_145	1_201
1_220	2_220
1_221	2_221
1_224	2_224
1_227	2_227
1_258	1_318
1_364	1_422
2_22	2_96
2_132	4_219
2_145	2_201
2_258	2_318
2_364	2_422
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_294
N	2_294

Related Record Type Details


					4CH8636GFF

INSULIN RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

ALLOSTERIC INHIBITOR

Amount:

Related Record Type Details


					QD87BSP58N

Ersodetug

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL