U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H24N2.2ClH.H2O
Molecular Weight 371.344
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAMIPINE DIHYDROCHLORIDE MONOHYDRATE

SMILES

O.Cl.Cl.CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=XUECZOCSQRYAQY-UHFFFAOYSA-N
InChI=1S/C19H24N2.2ClH.H2O/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17;;;/h2-11,19H,12-16H2,1H3;2*1H;1H2

HIDE SMILES / InChI

Molecular Formula C19H24N2
Molecular Weight 280.4073
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Bamipine (trade name Soventol) is a sedating antihistamine with pronounced sedative effects. Bamipine is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. Bamipine hydrochloride has been given by mouth. Bamipine, bamipine lactate, and bamipine salicylate have all been applied topically.

CNS Activity

Curator's Comment: Bamipine is an antihistamine with pronounced sedative effects.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Soventol

Approved Use

Allergic conditions
PubMed

PubMed

TitleDatePubMed
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.
2007 Dec 1
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.
2008 Dec 15
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can be used topically: A thin layer applied on the surface of the skin. Re-application is possible in 30 min. Duration of treatment depends on allergic process. http://www.druginfosys.com/drug.aspx?drugcode=1567&type=1
The recommended dose is 50-100 mg 3-4 times/day.
Route of Administration: Oral
Bamipine treatment resulted in 29% of inhibition of Mycobacterium tuberculosis H37Rv (after 4 days by microplate alamar blue assay) at 6.25 ug/mL.
Substance Class Chemical
Created
by admin
on Sat Dec 16 06:34:50 GMT 2023
Edited
by admin
on Sat Dec 16 06:34:50 GMT 2023
Record UNII
QAR6L248EA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAMIPINE DIHYDROCHLORIDE MONOHYDRATE
Common Name English
4-PIPERIDINAMINE, 1-METHYL-N-PHENYL-N-(PHENYLMETHYL)-, DIHYDROCHLORIDE, MONOHYDRATE
Common Name English
4-PIPERIDINAMINE, 1-METHYL-N-PHENYL-N-(PHENYLMETHYL)-, HYDROCHLORIDE, HYDRATE (1:2:1)
Systematic Name English
Code System Code Type Description
CAS
63560-99-6
Created by admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
PRIMARY
FDA UNII
QAR6L248EA
Created by admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
PRIMARY
PUBCHEM
71587218
Created by admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
PRIMARY
EPA CompTox
DTXSID70212951
Created by admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE