ISOMAZOLE HYDROCHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C14H13N3O2S.ClH
Molecular Weight	323.798
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=C(C=CC(=C1)[S+](C)[O-])C2=NC3=CC=NC=C3N2

InChI

InChIKey=OJDNVOWLGHYRPR-UHFFFAOYSA-N

InChI=1S/C14H13N3O2S.ClH/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14;/h3-8H,1-2H3,(H,16,17);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3999023 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.1987.tb00509.x

ISOMAZOLE is a cardiovascular agent with both inotropic and vasodilator activities. It acts primarily as a phosphodiesterase inhibitor.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.	1985 May	3999023
Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).	1986 Apr	3007737
Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats.	1989 Oct	2612774
Toxicological evaluation of the cardiotonic isomazole in the dog.	1989 Oct	2612775

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:27:15 GMT 2023` Edited by `admin` on `Fri Dec 15 17:27:15 GMT 2023`
Record UNII	QA075T23R1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ISOMAZOLE HYDROCHLORIDE

Official Name

English

ISOMAZOLE HYDROCHLORIDE [USAN]

Common Name

English

LY 175326

Code

English

1H-IMIDAZO(4,5-C)PYRIDINE, 2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-, MONOHYDROCHLORIDE

Common Name

English

LY-175326

Code

English

ISOMAZOLE HCL

Common Name

English

2-[2-Methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine monohydrochloride

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID801007502