ISOMAZOLE HYDROCHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C14H13N3O2S.ClH
Molecular Weight	323.798
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC(=CC=C1C2=NC3=C(N2)C=NC=C3)[S+](C)[O-]

InChI

InChIKey=OJDNVOWLGHYRPR-UHFFFAOYSA-N

InChI=1S/C14H13N3O2S.ClH/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14;/h3-8H,1-2H3,(H,16,17);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3999023 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.1987.tb00509.x

ISOMAZOLE is a cardiovascular agent with both inotropic and vasodilator activities. It acts primarily as a phosphodiesterase inhibitor.

Originator

Approval Year

PubMed

Title	Date	PubMed
Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats.	1989-10	2612774
Toxicological evaluation of the cardiotonic isomazole in the dog.	1989-10	2612775
Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).	1986-04	3007737
Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.	1985-05	3999023

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:46:42 GMT 2025` Edited by `admin` on `Mon Mar 31 18:46:42 GMT 2025`
Record UNII	QA075T23R1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LY 175326

Preferred Name

English

ISOMAZOLE HYDROCHLORIDE

Official Name

English

ISOMAZOLE HYDROCHLORIDE [USAN]

Common Name

English

1H-IMIDAZO(4,5-C)PYRIDINE, 2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-, MONOHYDROCHLORIDE

Common Name

English

LY-175326

Code

English

ISOMAZOLE HCL

Common Name

English

2-[2-Methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine monohydrochloride

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID801007502