Atigotatug

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:02:40 GMT 2025` Edited by `admin` on `Tue Apr 01 22:02:40 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Q8PK97HY9B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BMS-986012

Preferred Name

English

Atigotatug

Official Name

English

immunoglobulin G1-kappa, anti-[Fucosyl-GM1 (fucosylated monosialoganglioside 1)], Homo sapiens monoclonal antibody; H-gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV3-48*02 (90.7%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (117), CDR-IMGT [8.8.15]

Common Name

English

ATIGOTATUG [USAN]

Common Name

English

atigotatug [INN]

Common Name

English

BMS-986012 (HUMAN ANTIFUCOSYL-GM1 ANTIBODY)

Common Name

English

Immunoglobulin G1 [de-C-terminal lysine], anti-(fucosyl ganglioside GM1) (human monoclonal BMS-986012 ?1-chain), disulfide with human monoclonal BMS-986012 ?-chain, dimer

Common Name

English

Code System Code Type Description

CAS

1894272-37-7

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

NO STRUCTURE GIVEN

CAS

2733581-82-1

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

FDA UNII

Q8PK97HY9B

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

INN

12472

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

DRUG BANK

DB14831

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

NCI_THESAURUS

C118443

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

USAN

NO-22

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

SMS_ID

100000182718

Created by admin on Tue Apr 01 22:02:40 GMT 2025 , Edited by admin on Tue Apr 01 22:02:40 GMT 2025

PRIMARY

From	To
4_134	4_194
3_134	3_194
4_23	4_88
3_23	3_88
2_372	2_430
1_372	1_430
1_234	2_234
1_231	2_231
2_225	4_214
1_225	3_214
2_266	2_326
1_266	1_326
2_149	2_205
1_149	1_205
1_22	1_96
2_22	2_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					07D35C4DO9

FUCOSYL GM1 GANGLIOSIDE

TARGET->LIGAND

Amount:

Related Record Type Details


					Q8PK97HY9B

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL