ONTORPACEPT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:34:56 GMT 2025` Edited by `admin` on `Tue Apr 01 22:34:56 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Q8A4U1Z9N2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ontorpacept [INN]

Preferred Name

English

ONTORPACEPT

Official Name

English

Ontorpacept [WHO-DD]

Common Name

English

HUMAN SIGNAL-REGULATORY PROTEIN ALPHA (SIRP.ALPHA., TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, INHIBITORY RECEPTOR SHPS-1), (L14>S, T20>S, T22>I, R24>H, A27>V, G45>A, D65>E, L66>S, N70>E, R77>S, G79>S, D101>DEL, V102>T101)-VARIANT, N-TER

Common Name

English

1-118-SIGNAL REGULATORY PROTEIN .ALPHA. (HUMAN) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT), DIMER

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

624917

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C125718

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

PRIMARY

CAS

1615245-83-4

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

NO STRUCTURE GIVEN

FDA UNII

Q8A4U1Z9N2

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

PRIMARY

CAS

2131089-46-6

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

PRIMARY

SMS_ID

300000024160

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

PRIMARY

INN

10927

Created by admin on Tue Apr 01 22:34:56 GMT 2025 , Edited by admin on Tue Apr 01 22:34:56 GMT 2025

PRIMARY

From	To
1_25	1_91
1_124	2_124
1_127	2_127
1_159	1_219
1_265	1_323
2_25	2_91
2_159	2_219
2_265	2_323

Glycosylation Link Type	Site
N	1_80
N	1_195
N	2_80
N	2_195

Related Record Type Details


					90DHW5TM9S

LEUKOCYTE SURFACE ANTIGEN CD47

TARGET -> INHIBITOR

Related Record Type Details


					Q8A4U1Z9N2

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_345] [2_345]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL