Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H24N2.ClH |
| Molecular Weight | 352.9 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C(CC1=C2C=CC=CC2=NC(=C1)C3=CC=CC=C3)C4CCNCC4
InChI
InChIKey=JWEMPGHGMSUJIS-UHFFFAOYSA-N
InChI=1S/C22H24N2.ClH/c1-2-6-18(7-3-1)22-16-19(11-10-17-12-14-23-15-13-17)20-8-4-5-9-21(20)24-22;/h1-9,16-17,23H,10-15H2;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C22H24N2 |
| Molecular Weight | 316.4394 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of GABA on in vitro binding of two novel non-benzodiazepines, PK 8165 and CGS 8216, to benzodiazepine receptors in the rat brain. | 1982 Jul 5 |
|
| Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors. | 1984 Oct |
|
| Biochemical evidence that 2-phenyl-4[(4-piperidinyl) ethyl]quinoline, a quinoline derivative with pure anticonflict properties, is a partial agonist of benzodiazepine receptors. | 1984 Oct |
|
| Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. | 1987 Sep |
Patents
Sample Use Guides
healthy volunteers: 50 - 150 mg. administration route is not specified.
Route of Administration:
Unknown
In vitro studies of rat cuneate nucleus indicated that the proconvulsant actions of PK 8165 could be explained by its direct, albeit slightly different, interactions with the GABA-receptor complex. PK 8165 (100 microM) alone had no effect on responses to the GABA analogue muscimol, but enhanced the potency of picrotoxin as an antagonist of muscimol and reduced the potency of flurazepam as a potentiator of muscimol.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:50:17 GMT 2023
by
admin
on
Fri Dec 15 15:50:17 GMT 2023
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| Record UNII |
Q81XB10I9Z
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID00230168
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Q81XB10I9Z
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3062086
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80221-58-5
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admin on Fri Dec 15 15:50:17 GMT 2023 , Edited by admin on Fri Dec 15 15:50:17 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
