Tivinectide

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:18:29 GMT 2025` Edited by `admin` on `Wed Apr 02 11:18:29 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Q5Z4Q4M8AW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tivinectide

Official Name

English

N6.5,N6.5'-({12-[2-(2-{2-[3-oxo-3-({S3.1,S3.5,S3.15-[(1,3,5-triazinane-1,3,5-triyl)tris(3-oxopropane-3,1-diyl)][L-cysteinyl-L-prolyl-3-(naphthalen-1-yl)-L-alanyl-L-?-aspartyl-L-cysteinyl-L-methi

Preferred Name

English

tivinectide [INN]

Common Name

English

L-Alaninamide, 5,5?-[[12-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethyl]-3,6,9,15,18,21-hexaoxa-12-azatricosane-1,23-diyl]bis[1H-1,2,3-triazole-1,4-diyl(1-oxo-3,1-propanediyl)]]bis[N-acetyl-S-[3-oxo-3-[tetrahydro-3,5-bis(3-mercapto-1-oxopropyl)-1,3,5-tria

Common Name

English

Code System Code Type Description

INN

13475

Created by admin on Wed Apr 02 11:18:29 GMT 2025 , Edited by admin on Wed Apr 02 11:18:29 GMT 2025

PRIMARY

CAS

2762739-36-4

Created by admin on Wed Apr 02 11:18:29 GMT 2025 , Edited by admin on Wed Apr 02 11:18:29 GMT 2025

PRIMARY

FDA UNII

Q5Z4Q4M8AW

Created by admin on Wed Apr 02 11:18:29 GMT 2025 , Edited by admin on Wed Apr 02 11:18:29 GMT 2025

PRIMARY

Linkage Type	Residue Index
Cys-linker-Lys	1_5	2_5	3_1	3_5	3_15
Cys-linker-Cys-linker-Cys	1_1	1_8	1_15
Lys-PEG-Cys-PEG-Cys	1_5	2_5	3_1
Cys-linker-Cys-linker-Cys	2_1	2_8	2_15

Related Record Type Details


					Q5Z4Q4M8AW

Tivinectide

ACTIVE MOIETY

Comments:

immunostimulant, antineoplastic

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_14] [2_14]	SITE_SPECIFIC	Amount:	NORLEUCINE	832C8OV84S
AMINO_ACID_SUBSTITUTION	[2_1] [2_8] [2_15]			UNSPECIFIED SUBSTANCE	6abca28f (not in database)
AMINO_ACID_SUBSTITUTION	[1_5] [2_5] [3_1] [3_5] [3_15]	SITE_SPECIFIC		UNSPECIFIED SUBSTANCE	5149a740 (not in database)
AMINO_ACID_SUBSTITUTION	[3_7]	SITE_SPECIFIC		HOMOARGININE, L-	JF751CK38I
AMINO_ACID_SUBSTITUTION	[3_13]	SITE_SPECIFIC		HYDROXYPROLINE	RMB44WO89X
AMINO_ACID_SUBSTITUTION	[1_16] [2_16]	SITE_SPECIFIC	Amount:	ALANINAMIDE, L-	GOD06L4T27
AMINO_ACID_SUBSTITUTION	[1_1] [1_8] [1_15]			UNSPECIFIED SUBSTANCE	6abca28f (not in database)
AMINO_ACID_SUBSTITUTION	[3_3]	SITE_SPECIFIC		1-NAPHTHYL-L-ALANINE	9G930UL92R
AMINO_ACID_SUBSTITUTION	[1_2] [2_2]	SITE_SPECIFIC	Amount:	UNSPECIFIED SUBSTANCE	b75ae2f6 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL