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Details

Stereochemistry ACHIRAL
Molecular Formula C6H11NO2.ClH.H2O
Molecular Weight 183.633
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYCLOLEUCINE HYDROCHLORIDE MONOHYDRATE

SMILES

O.Cl.NC1(CCCC1)C(O)=O

InChI

InChIKey=REDNUMWNGCRGNH-UHFFFAOYSA-N
InChI=1S/C6H11NO2.ClH.H2O/c7-6(5(8)9)3-1-2-4-6;;/h1-4,7H2,(H,8,9);1H;1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H11NO2
Molecular Weight 129.157
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Glutamate induces different neuronal conditioned responses than ACPD when used as a locally ionophoresed unconditioned stimulus in the cat motor cortex.
2002
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.
2002 Dec
Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors.
2002 Dec
Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.
2002 Nov
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
2002 Nov 1
Enantioselective synthesis of the excitatory amino acid (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid.
2002 Nov 1
Cell type-selective expression of green fluorescent protein and the calcium indicating protein, yellow cameleon, in rat cortical primary cultures.
2002 Nov 29
A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic.
2002 Oct 4
Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.
2002 Sep
Spatial segregation and interaction of calcium signalling mechanisms in rat hippocampal CA1 pyramidal neurons.
2002 Sep 1
Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro.
2002 Sep 6
Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats.
2003
Expression of angiogenic factors in hepatocellular carcinoma after transcatheter arterial chemoembolization.
2003
Effects of a selective metabotropic glutamate receptor agonist on the micturition reflex pathway in urethane-anesthetized rats.
2003
Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area.
2003
Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission.
2003
Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.
2003 Apr
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
2003 Apr
Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling.
2003 Apr
Cooperativity between activation of metabotropic glutamate receptors and NMDA receptors in the induction of LTP in hippocampal CA1 neurons.
2003 Aug
Functional synaptic contacts by intranuclear axon collaterals of thalamic relay neurons.
2003 Aug 20
Characterization of S-adenosylmethionine synthetase in Cryptosporidium parvum (Apicomplexa).
2003 Aug 29
Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.
2003 Aug 30
Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.
2003 Dec
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
2003 Dec 1
The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid.
2003 Feb 21
Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.
2003 Jan
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
2003 Jan 23
Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex.
2003 Jan 31
Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.
2003 Jul
Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells.
2003 Jul
Accommodation of alpha-substituted residues in the beta-peptide 12-helix: expanding the range of substitution patterns available to a foldamer scaffold.
2003 Jul 16
Endogenous zinc as a retinal neuromodulator: evidence from the skate (Raja erinacea).
2003 Jul 17
The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats.
2003 Jun
S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes.
2003 Jun
Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons.
2003 Jun 1
Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.
2003 Jun 16
Peptide backbone folding induced by the C(alpha)-tetrasubstituted cyclic alpha-amino acids 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) and 1-aminocyclopentane-1-carboxylic acid (Ac5c). A joint computational and experimental study.
2003 Jun 7
Activation of Ih is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 region.
2003 Mar
Roles of ionotropic glutamate receptors in early developing neurons derived from the P19 mouse cell line.
2003 Mar-Apr
Alpha-cycloPNA: 1-aminocylopentane-1-carboxylic acid-derived peptide nucleic acid.
2003 May-Aug
Structure of glutamate analogs that activate the ON bipolar cell metabotropic glutamate receptor in vertebrate retina.
2003 May-Jun
Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model.
2003 Nov
Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons.
2003 Sep
Metabotropic glutamate receptors (mGluRs) are involved in early phase of memory formation: possible role of modulation of glutamate release.
2003 Sep-Oct
NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.
2004 Apr
Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells.
2004 Jan 15
Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides.
2004 Jan 16
S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
2004 Jul
NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats.
2004 May
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 02:55:30 GMT 2023
Edited
by admin
on Sat Dec 16 02:55:30 GMT 2023
Record UNII
Q54GQ146M2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYCLOLEUCINE HYDROCHLORIDE MONOHYDRATE
MI  
Common Name English
CYCLOPENTANECARBOXYLIC ACID, 1-AMINO-, HYDROCHLORIDE, HYDRATE (1:1:1)
Common Name English
1-AMINOCYCLOPENTANECARBOXYLIC ACID HYDROCHLORIDE MONOHYDRATE
Systematic Name English
CYCLOPENTANECARBOXYLIC ACID, 1-AMINO-, HYDROCHLORIDE, MONOHYDRATE
Common Name English
CYCLOLEUCINE HYDROCHLORIDE MONOHYDRATE [MI]
Common Name English
Code System Code Type Description
FDA UNII
Q54GQ146M2
Created by admin on Sat Dec 16 02:55:30 GMT 2023 , Edited by admin on Sat Dec 16 02:55:30 GMT 2023
PRIMARY
CAS
66146-62-1
Created by admin on Sat Dec 16 02:55:30 GMT 2023 , Edited by admin on Sat Dec 16 02:55:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID30216334
Created by admin on Sat Dec 16 02:55:30 GMT 2023 , Edited by admin on Sat Dec 16 02:55:30 GMT 2023
PRIMARY
PUBCHEM
71369749
Created by admin on Sat Dec 16 02:55:30 GMT 2023 , Edited by admin on Sat Dec 16 02:55:30 GMT 2023
PRIMARY
MERCK INDEX
m3997
Created by admin on Sat Dec 16 02:55:30 GMT 2023 , Edited by admin on Sat Dec 16 02:55:30 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE