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Details

Stereochemistry ACHIRAL
Molecular Formula C18H37N.FH
Molecular Weight 287.4994
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of DECTAFLUR

SMILES

F.CCCCCCCC\C=C/CCCCCCCCN

InChI

InChIKey=QGSCPWWHMSCFOV-KVVVOXFISA-N
InChI=1S/C18H37N.FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19;/h9-10H,2-8,11-19H2,1H3;1H/b10-9-;

HIDE SMILES / InChI

Molecular Formula C18H37N
Molecular Weight 267.4931
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula FH
Molecular Weight 20.00634
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:17:27 GMT 2025
Edited
by admin
on Mon Mar 31 18:17:27 GMT 2025
Record UNII
Q3B1Y93C1S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SK&F 38094
Preferred Name English
DECTAFLUR
INN   MART.   USAN   WHO-DD  
INN   USAN  
Official Name English
Dectaflur [WHO-DD]
Common Name English
9-Octadecenylamine hydrofluoride
Systematic Name English
9Z-OCTADECENYLAMINE HYDROFLUORIDE
Common Name English
dectaflur [INN]
Common Name English
SK&F-38094
Code English
DECTAFLUR [USAN]
Common Name English
OLEYL AMINE HYDROFLUORIDE
Systematic Name English
DECTAFLUR [MART.]
Common Name English
9-OCTADECEN-1-AMINE, HYDROFLUORIDE (1:1), (9Z)-
Common Name English
OLEYLAMINE HYDROFLUORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C26170
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C83656
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
FDA UNII
Q3B1Y93C1S
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
CAS
7333-84-8
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
MESH
C008703
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
WIKIPEDIA
Dectaflur
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
SMS_ID
100000083475
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
CAS
36505-83-6
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
NON-SPECIFIC STEREOCHEMISTRY
EPA CompTox
DTXSID7073484
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
PUBCHEM
20838116
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
EVMPD
SUB06939MIG
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110897
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
INN
3373
Created by admin on Mon Mar 31 18:17:28 GMT 2025 , Edited by admin on Mon Mar 31 18:17:28 GMT 2025
PRIMARY
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ACTIVE MOIETY