Xirestomig

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:43:59 GMT 2025` Edited by `admin` on `Wed Apr 02 12:43:59 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Q2C2VG7V4N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ATG-101

Preferred Name

English

Xirestomig

Official Name

English

xirestomig [INN]

Common Name

English

Immunoglobulin G1 [301-alanine], bispecific, anti-(programmed death-ligand 1) (human monoclonal ATG-101 ?1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with immunoglobulin anti-(human tumor necrosis factor receptor TNFRSF9) (human si

Common Name

English

ATG101

Code

English

immunoglobulin G1-scFv_L2 dimer, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1,B7 homolog 1, B7H1, B7-H1, PDCD1LG1) and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9,4-1BB, T cell antigen ILA, CD137)], Homo sapie

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

899222

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

Code System Code Type Description

FDA UNII

Q2C2VG7V4N

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

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NCI_THESAURUS

C190124

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

PRIMARY

INN

12746

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

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CAS

2756879-35-1

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

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SMS_ID

300000051888

Created by admin on Wed Apr 02 12:43:59 GMT 2025 , Edited by admin on Wed Apr 02 12:43:59 GMT 2025

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From	To
4_139	4_198
4_22	4_90
3_139	3_198
3_22	3_90
2_624	2_691
2_486	2_560
2_371	2_429
2_265	2_325
2_224	4_216
2_148	2_204
2_22	2_96
1_624	1_691
1_486	1_560
1_371	1_429
1_265	1_325
1_233	2_233
1_230	2_230
1_224	3_216
1_148	1_204
1_22	1_96

Related Record Type Details


					Q2C2VG7V4N

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL