.ALPHA.-ACETYLDIGOXIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H66O15
Molecular Weight	822.9751
Optical Activity	UNSPECIFIED
Defined Stereocenters	21 / 21
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(C[C@H](O)[C@H](O[C@@]2([H])C[C@H](O)[C@H](O[C@@]3([H])C[C@H](OC(C)=O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1)O[C@H]4CC[C@@]5(C)[C@]([H])(CC[C@]6([H])[C@]5([H])C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4

InChI

InChIKey=HWKJSYYYURVNQU-DXJNJSHLSA-N

InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C43H66O15
Molecular Weight	822.9751
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	21 / 21
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://doi.org/10.4070/kcj.1975.5.1.31 | https://www.ncbi.nlm.nih.gov/pubmed/7042270

Acetyldigoxin, a cardiac glycoside that has been studied in patients with congestive heart failure.

Approval Year

PubMed

Title	Date	PubMed
[Cardiotonic and cardiotoxic properties of acetyldigoxin].	1963 Feb 5	14035219
[Acetyldigoxin. Clinical study in 25 patients].	1963 May	13928628
[Pharmacological properties of alpha-acetyldigoxin].	1966 Apr	5940214
[Management of heart insufficiency using alpha-acetyldigoxin].	1967 May 12	5631236

Sample Use Guides

In Vivo Use Guide

For rapid digitalization in 2-3 days, the initial dose was 1.2 to 2.6mg (average 1.96mg). For medium-fast digitalization in 4 days, the loading dose was 2.0 to 3.2mg (average 2.7mg). For slow digitalization 0.1 to 0.4mg was required for 5 to 6 days without loading dose. The maintenance dose was 0.1 to 0.4mg (average 0.33mg) daily.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:49:50 GMT 2023` Edited by `admin` on `Sat Dec 16 01:49:50 GMT 2023`
Record UNII	Q28IFH7A50
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

.ALPHA.-ACETYLDIGOXIN

Common Name

English

ACETYLDIGOXIN

Common Name

English

.ALPHA.-ACETYLDIGOXIN [MI]

Common Name

English

Acetyldigoxin [WHO-DD]

Common Name

English

3.BETA.-((3-O-ACETYL-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE

Systematic Name

English

LANATILIN

Brand Name

English

DIGOXIN IMPURITY I [EP IMPURITY]

Common Name

English

DIGOXIN, 3'''-ACETATE

Common Name

English

SANDOLANID

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QC01AA52