MT-45

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H32N2
Molecular Weight	348.5243
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MT-45

Structure Search

SMILES

C(C(N1CCN(CC1)C2CCCCC2)C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=IGBRRSIHEGCUEN-UHFFFAOYSA-N

InChI=1S/C24H32N2/c1-4-10-21(11-5-1)20-24(22-12-6-2-7-13-22)26-18-16-25(17-19-26)23-14-8-3-9-15-23/h1-2,4-7,10-13,23-24H,3,8-9,14-20H2

HIDE SMILES / InChI

Molecular Formula	C24H32N2
Molecular Weight	348.5243
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Mu opioid receptor 231 Target ID: CHEMBL233 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29973882	Agonist 2752		44.0 nM [Ki]
Delta opioid receptor 81 Target ID: CHEMBL236 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29973882	Agonist 2752		606.0 nM [Ki]
Kappa opioid receptor 115 Target ID: CHEMBL237 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29973882	Agonist 2752		204.0 nM [Ki]

PubMed

PubMed

Title	Date	PubMed
Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells.	2001	11680691

Patents

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:12:03 GMT 2025` Edited by `admin` on `Mon Mar 31 21:12:03 GMT 2025`
Record UNII	Q2640DPW33
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IC-6

Preferred Name

English

MT-45

Common Name

English

MT 45 [WHO-DD]

Common Name

English

1- CYCLOHEXYL-4-(1,2-DIPHENYLETHYL)PIPERAZINE

Systematic Name

English

PIPERAZINE, 1-CYCLOHEXYL-4-(1,2-DIPHENYLETHYL)-

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-MT-45

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

DEA NO.

9560

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

Code System Code Type Description

PUBCHEM

431865

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

SMS_ID

100000167472

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

WIKIPEDIA

MT-45

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

CAS

52694-55-0

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

FDA UNII

Q2640DPW33

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

EVMPD

SUB181664

Created by admin on Mon Mar 31 21:12:03 GMT 2025 , Edited by admin on Mon Mar 31 21:12:03 GMT 2025

PRIMARY

Related Record Type Details


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1-Cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine

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1-Cyclohexyl-4-[(1S)-1,2-diphenylethyl]piperazine

ENANTIOMER -> RACEMATE

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Comments:

Inhibition of cAMP accumulation

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Comments:

??arrestin2 recruitment

Qualification:

EC50

Amount:


					97XE3EK697

BETA-ARRESTIN-2

TARGET -> INHIBITOR

Comments:

??arrestin2 recruitment

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					EB2C2TKJ67

MT-45 hydrochloride

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					Q2640DPW33

MT-45

ACTIVE MOIETY