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Details

Stereochemistry MIXED
Molecular Formula C14H29O4S.Na
Molecular Weight 316.432
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM TETRADECYL SULFATE

SMILES

[Na+].CCCCC(CC)CCC(CC(C)C)OS([O-])(=O)=O

InChI

InChIKey=FVEFRICMTUKAML-UHFFFAOYSA-M
InChI=1S/C14H30O4S.Na/c1-5-7-8-13(6-2)9-10-14(11-12(3)4)18-19(15,16)17;/h12-14H,5-11H2,1-4H3,(H,15,16,17);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C14H29O4S
Molecular Weight 293.443
Charge -1
Count
Stereochemistry MIXED
Additional Stereochemistry
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. Sodium tetradecyl sulfate is the active component of the sclerosant drug Sotradecol. Sotradecol (sodium tetradecyl sulfate injection) is a sclerosing agent. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent. Sotradecol® (sodium tetradecyl sulfate injection) is indicated in the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. The benefit-to-risk ratio should be considered in selected patients who are great surgical risks. Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation. In the UK, Ireland, Italy, Australia, New Zealand and South Africa, it is sold under the trade-name Fibro-Vein in concentrations of 0.2%, 0.5%, 1.0%, and 3%

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Sclerosant treatment of varicose veins and deep vein thrombosis.
1984 Nov
[Cardiorespiratory arrest after injection of Trombovar (sodium tetradecyl sulfate)].
1993 Sep-Oct
Chronic facial pain following injection of sodium tetradecyl sulphate into an intraparotid haemolymphangioma.
2008 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Sotradecol (sodium tetradecyl sulfate injection) is for intravenous use only. The strength of solution required depends on the size and degree of varicosity. In general, the 1% solution will be found most useful with the 3% solution preferred for larger varicosities. The dosage should be kept small, using 0.5 mL to 2 mL (preferably 1 mL maximum) for each injection, and the maximum single treatment should not exceed 10 mL.
Route of Administration: Intravenous
In Vitro Use Guide
Sodium tetradecyl sulfate inhibited flagellation, motility, swarming, and growth of Proteus (inhibitory concentration, 0.1 to 0.5 mmoles per liter). At a concentration of 0.1 mmole per liter, sodium tetradecyl sulfate completely inhibited the motility of Proteus in the liquid medium employed without impairing growth.
Substance Class Chemical
Created
by admin
on Tue Oct 22 06:21:36 UTC 2019
Edited
by admin
on Tue Oct 22 06:21:36 UTC 2019
Record UNII
Q1SUG5KBD6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM TETRADECYL SULFATE
INN   MART.   MI   ORANGE BOOK   VANDF   WHO-DD  
INN  
Official Name English
SOTRADECOL
Brand Name English
SODIUM TETRADECYL SULFATE [VANDF]
Common Name English
SODIUM TETRADECYLSULFATE
Systematic Name English
SODIUM TETRADECYL SULFATE [MART.]
Common Name English
SODIUM TETRADECYL SULFATE [MI]
Common Name English
SODIUM TETRADECYL SULFATE [WHO-DD]
Common Name English
SODIUM TETRADECYL SULFATE [ORANGE BOOK]
Common Name English
7-ETHYL-2-METHYL-4-UNDECANOLSULFATE, SODIUM SALT
Common Name English
SODIUM TETRADECYL SULPHATE
Systematic Name English
SODIUM 7-ETHYL-2-METHYL-4-UNDECANOL SULFATE
Systematic Name English
FIBROVEIN
Brand Name English
SODIUM TETRADECYL SULFATE [INN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 12786
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
NCI_THESAURUS C78275
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
WHO-ATC C05BB04
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
WHO-VATC QC05BB04
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
Code System Code Type Description
ChEMBL
CHEMBL1201345
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
MESH
D012981
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
EVMPD
SUB10571MIG
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
PUBCHEM
23665772
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
NCI_THESAURUS
C66555
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
CAS
139-88-8
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
INN
130
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
RXCUI
9913
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY RxNorm
ECHA (EC/EINECS)
205-380-3
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
EPA CompTox
139-88-8
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY
MERCK INDEX
M10087
Created by admin on Tue Oct 22 06:21:36 UTC 2019 , Edited by admin on Tue Oct 22 06:21:36 UTC 2019
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY