PERFLUBRON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8BrF17
Molecular Weight	498.962
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br

InChI

InChIKey=WTWWXOGTJWMJHI-UHFFFAOYSA-N

InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26

HIDE SMILES / InChI

Molecular Formula	C8BrF17
Molecular Weight	498.962
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Perflubron is a contrast agent used for signal enhancement during the indicated ultrasound imaging procedures. Perflubron is a constituent of blood substitute, indicated for liquid breathing.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Contrast agent for CT, sonography, and MR imaging 1	Diagnostic		Approved 8,429	IMAGENT

C_max

C_max

Value	Dose	Co-administered	Analyte	Population
0.16 mg/dL	14 mL/kg single, respiratory		PERFLUBRON serum	Homo sapiens

Sourcing

Sourcing

Show entries

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:38803	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:38803
ChemicalBook	CB5409529	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5409529
eMolecules	499692	https://www.emolecules.com/cgi-bin/more?vid=499692
MolPort	MolPort-001-776-498	https://www.molport.com/shop/molecule-link/MolPort-001-776-498
ZINC	ZINC000008214650	http://zinc15.docking.org/substances/ZINC000008214650

Showing 1 to 5 of 5 entries

Previous1Next

PubMed

Show entries

Title	Date	PubMed
High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: dose-response relationships in an animal model of acute lung injury.	2001 Apr	11373481
[Effects of positive end-expiratory pressure, tidal volume and perflubron doses on gas exchange during partial liquid ventilation].	2001 Feb	11244763
Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury.	2001 Mar	11355128
Seventy-two hours hypothermic intestinal preservation study using a new perfluorocarbon emulsion.	2001 May	11358038
Oxygen carriers.	2002 Aug	12211412

Showing 1 to 5 of 30 entries

Previous1 2 3 4 5 6Next

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 0.00625 mL/kg (0.125 mg/kg) administered as a single intravenous bolus over a period of not less than 10 seconds and immediately followed by a saline flush.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	Q1D0Q7R4D9
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

PERFLUBRON

Official Name

English

N-PERFLUOROOCTYL BROMIDE

Common Name

English

PERFLUBRON [USP-RS]

Common Name

English

OCTANE, 1-BROMO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-HEPTADECAFLUORO-

Systematic Name

English

PERFLUOROCTYL BROMIDE

Common Name

English

Showing 1 to 5 of 20 entries

Previous1 2 3 4Next

Show entries

Classification Tree

Code System

Code

Other magnetic resonance imaging contrast media

WHO-VATC

QV08CX01

Designated

FDA ORPHAN DRUG

630718

Designated

FDA ORPHAN DRUG

631018

Imaging Agent

NCI_THESAURUS

C390

Other magnetic resonance imaging contrast media

WHO-ATC

V08CX01

Showing 1 to 5 of 7 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

DRUG BANK

DB05791

PRIMARY

EVMPD

SUB09721MIG

PRIMARY

USAN

DD-10

PRIMARY

ChEMBL

CHEMBL1200866

PRIMARY

DRUG CENTRAL

2102

PRIMARY

Showing 1 to 5 of 18 entries

Previous1 2 3 4Next

Show entries

Related Record

Type

Details


					Q1D0Q7R4D9

PERFLUBRON

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

Previous1Next

SMILES

InChI

Originator

Approval Year

Conditions

Cmax

Sourcing

PubMed

Patents

Sample Use Guides

C_max