Nendocabtagene Onogedleucel

Investigational

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 08:40:23 GMT 2025` Edited by `admin` on `Wed Apr 02 08:40:23 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cells
Fraction Name	t cell
Record UNII	Q137JC2CLV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Nendocabtagene Onogedleucel

Official Name

English

ALLO 715

Preferred Name

English

ALLO 715 [WHO-DD]

Common Name

English

nendocabtagene onogedleucel [INN}

Common Name

English

allogeneic T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis of healthy volunteer donors, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B-ce

Common Name

English

ALLO-715

Code

English

ALLO715

Code

English

Anti-BCMA CAR T-cell therapy ALLO715

Common Name

English

Notes: Allogenic T-cells expressing a chimeric antigen receptor directed to the B-cell maturation antigen (BCMA) for anticipated use in treating patients with multiple myeloma

Common Name

English

Code System Code Type Description

FDA UNII

Q137JC2CLV

Created by admin on Wed Apr 02 08:40:23 GMT 2025 , Edited by admin on Wed Apr 02 08:40:23 GMT 2025

PRIMARY

SMS_ID

300000033830

Created by admin on Wed Apr 02 08:40:23 GMT 2025 , Edited by admin on Wed Apr 02 08:40:23 GMT 2025

PRIMARY

NCI_THESAURUS

C165779

Created by admin on Wed Apr 02 08:40:23 GMT 2025 , Edited by admin on Wed Apr 02 08:40:23 GMT 2025

PRIMARY

CAS

2783320-97-6

Created by admin on Wed Apr 02 08:40:23 GMT 2025 , Edited by admin on Wed Apr 02 08:40:23 GMT 2025

PRIMARY

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TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					Q137JC2CLV

Nendocabtagene Onogedleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
TRANSESTERIFICATION	RECEPTOR EXPRESSION	LENTIVIRAL TRANSFECTION		Nendocabtagene onogedleucel lentiviral vector	9W1GUC1ESZ

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
PROTEIN NOT EXPRESSED (GENE DISRUPTION)	CAMPATH-1 ANTIGEN	80A297KX6N
VECTOR EXPRESSED PROTEIN	Nendocabtagene onogedleucel chimeric antigen receptor targeting human B-cell maturation antigen (BCMA) preprotein	A51N33N2QO
PROTEIN NOT EXPRESSED (GENE DISRUPTION)	HUMAN T-CELL ALPHA/BETA RECEPTOR	8OO8E2BVQ4