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Details

Stereochemistry ACHIRAL
Molecular Formula C15H12N5O4.K
Molecular Weight 365.3852
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LETEPRINIM POTASSIUM

SMILES

[K+].[O-]C(=O)C1=CC=C(NC(=O)CCN2C=NC3=C2N=CNC3=O)C=C1

InChI

InChIKey=MICLTPPSCUXHJT-UHFFFAOYSA-M
InChI=1S/C15H13N5O4.K/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22;/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C15H12N5O4
Molecular Weight 326.2869
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Leteprinim is the synthetic purine. It has both anti-excitotoxic neuroprotective properties and enhances the regenerative response of surviving neurons within the central nervous system. Moreover, the experiments in vitro and in vivo reveal that leteprinim can be administered after an excitotoxic event and still produce neuroprotection. This is clearly crucial for any drug designed to treat stroke or any acute central nervous system injury. Therefore, leteprinim has the pharmacological properties required by a drug intended to treat acute stroke as well as a spinal injury. It may be useful in reducing brain injury; it possesses clinical relevance for the treatment of hypoxic-ischemic encephalopathy in the newborn. Leteprinim has the therapeutic potential for use in clinical trials in the treatment of neuronal deterioration in depression.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P01138
Gene ID: 4803.0
Gene Symbol: NGF
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.
1999 Aug
Drugs in development for Parkinson's disease.
2004 Jul
AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats.
2004 Sep-Dec
Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response.
2006 Apr
Protection of sensory function in diabetic rats by Neotrofin.
2006 Mar 18
Small molecule activators of the Trk receptors for neuroprotection.
2008 Dec 3
Integrative emphases on intimate, intrinsic propensity/pathological processes--causes of self recovery limits and also, subtle related targets for neuroprotectionl pleiotropicity/multimodal actions, by accessible therapeutic approaches--in spinal cord injuries.
2010 Jul-Sep
Effects of neotrofin on neonatal hypoxic ischemic brain injury.
2011 Nov 14
Neuroprotective effect of neotrofin in a neonatal rat model of periventricular leukomalacia.
2012 Jun 27
Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat.
2013 Sep 15
Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease.
2016

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Rat data
60 mg/kg daily
Route of Administration: Intraperitoneal
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:16:29 GMT 2023
Edited
by admin
on Sat Dec 16 14:16:29 GMT 2023
Record UNII
Q06WU8JY4F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LETEPRINIM POTASSIUM
USAN  
USAN  
Official Name English
AIT-082
Code English
NEOTROFIN
Brand Name English
POTASSIUM 4-((3-(1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)-1-OXOPROPYL)AMINO)BENZOATE
Systematic Name English
LETEPRINIM POTASSIUM SALT [MI]
Common Name English
LETEPRINIM POTASSIUM [USAN]
Common Name English
POTASSIUM P-(3-(1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)PROPIONAMIDO)BENZOATE
Common Name English
LETEPRINIM POTASSIUM SALT
MI  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1509
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
Code System Code Type Description
USAN
KK-04
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
NCI_THESAURUS
C80996
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
CAS
192564-13-9
Created by admin on Sat Dec 16 14:16:29 GMT 2023 , Edited by admin on Sat Dec 16 14:16:29 GMT 2023
PRIMARY
FDA UNII
Q06WU8JY4F
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
PUBCHEM
101497201
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID00940917
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
MERCK INDEX
m1203
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL2104345
Created by admin on Sat Dec 16 14:16:30 GMT 2023 , Edited by admin on Sat Dec 16 14:16:30 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY