LETEPRINIM POTASSIUM

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H12N5O4.K
Molecular Weight	365.3852
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].[O-]C(=O)C1=CC=C(NC(=O)CCN2C=NC3=C2N=CNC3=O)C=C1

InChI

InChIKey=MICLTPPSCUXHJT-UHFFFAOYSA-M

InChI=1S/C15H13N5O4.K/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22;/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C15H12N5O4
Molecular Weight	326.2869
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22024506 | https://www.ncbi.nlm.nih.gov/pubmed/23850356 | https://www.ncbi.nlm.nih.gov/pubmed/15992149 | https://adisinsight.springer.com/drugs/800003615

Leteprinim is the synthetic purine. It has both anti-excitotoxic neuroprotective properties and enhances the regenerative response of surviving neurons within the central nervous system. Moreover, the experiments in vitro and in vivo reveal that leteprinim can be administered after an excitotoxic event and still produce neuroprotection. This is clearly crucial for any drug designed to treat stroke or any acute central nervous system injury. Therefore, leteprinim has the pharmacological properties required by a drug intended to treat acute stroke as well as a spinal injury. It may be useful in reducing brain injury; it possesses clinical relevance for the treatment of hypoxic-ischemic encephalopathy in the newborn. Leteprinim has the therapeutic potential for use in clinical trials in the treatment of neuronal deterioration in depression.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-nerve growth factor 2 Target ID: P01138 Gene ID: 4803.0 Gene Symbol: NGF Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18465624	Agonist 2752

PubMed

Title	Date	PubMed
Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease.	2016	27768761
Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat.	2013-09-15	23850356
Neuroprotective effect of neotrofin in a neonatal rat model of periventricular leukomalacia.	2012-06-27	22579826
Effects of neotrofin on neonatal hypoxic ischemic brain injury.	2011-11-14	22024506
Integrative emphases on intimate, intrinsic propensity/pathological processes--causes of self recovery limits and also, subtle related targets for neuroprotectionl pleiotropicity/multimodal actions, by accessible therapeutic approaches--in spinal cord injuries.	2010-10-16	20945817
Small molecule activators of the Trk receptors for neuroprotection.	2008-12-03	19090982
Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response.	2006-04	16467964
Protection of sensory function in diabetic rats by Neotrofin.	2006-03-18	16507305
AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats.	2004-10-06	15461869
Drugs in development for Parkinson's disease.	2004-07	15298067
AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.	1999-08	15992149

Sample Use Guides

In Vivo Use Guide

60 mg/kg daily

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Tue Apr 01 22:47:13 GMT 2025` Edited by `admin` on `Tue Apr 01 22:47:13 GMT 2025`
Record UNII	Q06WU8JY4F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LETEPRINIM POTASSIUM

Official Name

English

LETEPRINIM POTASSIUM SALT

Preferred Name

English

AIT-082

Code

English

NEOTROFIN

Brand Name

English

POTASSIUM 4-((3-(1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)-1-OXOPROPYL)AMINO)BENZOATE

Systematic Name

English

LETEPRINIM POTASSIUM SALT [MI]

Common Name

English

LETEPRINIM POTASSIUM [USAN]

Common Name

English

POTASSIUM P-(3-(1,6-DIHYDRO-6-OXO-9H-PURIN-9-YL)PROPIONAMIDO)BENZOATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509