FERTIRELIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Description

FERTIRELIN is an analog of luteinizing hormone releasing factor. The drug has been used since 1981 in Japan to treat various types of reproductive failure in cattle.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Gonadotropin-releasing hormone receptor 41	Agonist 2,752		0.7 nM [Ki]

PubMed

PubMed

Show entries

Title	Date	PubMed
Therapeutic effects of an analog of luteinizing hormone-releasing hormone (Des-Gly10-LH-RH-ethylamide) on cows with cystic ovary.	1980 Aug	7012414
New degradation product of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in aqueous solution.	1991 Feb	2051323
Characterization of 12 GnRH peptide agonists - a kinetic perspective.	2016 Jan	26398856

Showing 1 to 3 of 3 entries

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Q041AO6T91
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

TAP 031

Preferred Name

English

FERTIRELIN

Official Name

English

LUTEINIZING HORMONE-RELEASING FACTOR (PIG), 9-(N-ETHYL-L-PROLINAMIDE)-10-DEGLYCINAMIDE-

Common Name

English

TAP-031

Code

English

fertirelin [INN]

Common Name

English

Showing 1 to 5 of 8 entries

Previous1 2Next

Show entries

Classification Tree

Code System

Code

Gonadotropin-releasing hormones

WHO-VATC

QH01CA91

Therapeutic Hormone

NCI_THESAURUS

C1910

Showing 1 to 2 of 2 entries

Show entries

Code System

Code

Type

Description

ChEMBL

CHEMBL2110870

PRIMARY

MERCK INDEX

m5358

PRIMARY

Merck Index

EVMPD

SUB07615MIG

PRIMARY

PUBCHEM

188304

PRIMARY

INN

4675

PRIMARY

Showing 1 to 5 of 10 entries

Previous1 2Next

Subunit 0

Show entries

Related Record

Type

Details


					MJK4KMT12V

GONADOTROPIN-RELEASING HORMONE RECEPTOR

TARGET -> AGONIST

Amount:


					JD54DU77I8

FERTIRELIN ACETATE

SALT/SOLVATE -> PARENT

Showing 1 to 2 of 2 entries

Show entries

Related Record

Type

Details


					Q041AO6T91

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

Structural Modifications

Show entries

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_9]		P		L-PROLINE ETHYLAMIDE	16B70W94PN
AMINO_ACID_SUBSTITUTION	[1_1]		Q		PIDOLIC ACID	SZB83O1W42

Showing 1 to 2 of 2 entries

Show entries

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C55H76N16O12
MOL_WEIGHT:CALCULATED	CHEMICAL	CALCULATED 1153 Da (average)

Showing 1 to 2 of 2 entries