FERTIRELIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67009936 | https://www.ncbi.nlm.nih.gov/pubmed/2051323 | https://www.ncbi.nlm.nih.gov/pubmed/7012414

FERTIRELIN is an analog of luteinizing hormone releasing factor. The drug has been used since 1981 in Japan to treat various types of reproductive failure in cattle.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Gonadotropin-releasing hormone receptor 41 Target ID: CHEMBL1855 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26398856	Agonist 2752		0.7 nM [Ki]

PubMed

PubMed

Title	Date	PubMed
Characterization of 12 GnRH peptide agonists - a kinetic perspective.	2016-01	26398856
New degradation product of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in aqueous solution.	1991-02	2051323
Therapeutic effects of an analog of luteinizing hormone-releasing hormone (Des-Gly10-LH-RH-ethylamide) on cows with cystic ovary.	1980-08	7012414

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:37:22 GMT 2025` Edited by `admin` on `Mon Mar 31 20:37:22 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Q041AO6T91
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TAP 031

Preferred Name

English

FERTIRELIN

Official Name

English

LUTEINIZING HORMONE-RELEASING FACTOR (PIG), 9-(N-ETHYL-L-PROLINAMIDE)-10-DEGLYCINAMIDE-

Common Name

English

TAP-031

Code

English

fertirelin [INN]

Common Name

English

5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYLGLYCYL-L-LEUCYL-L-ARGINYL-N-ETHYL-L-PROLINAMIDE

Common Name

English

FERTIRELIN [JAN]

Common Name

English

FERTIRELIN [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH01CA91

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

NCI_THESAURUS

C1910

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

Code System Code Type Description

ChEMBL

CHEMBL2110870

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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MERCK INDEX

m5358

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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Merck Index

EVMPD

SUB07615MIG

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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PUBCHEM

188304

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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INN

4675

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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SMS_ID

100000080981

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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EPA CompTox

DTXSID8057728

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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CAS

38234-21-8

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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NCI_THESAURUS

C96854

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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FDA UNII

Q041AO6T91

Created by admin on Mon Mar 31 20:37:22 GMT 2025 , Edited by admin on Mon Mar 31 20:37:22 GMT 2025

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Related Record Type Details


					MJK4KMT12V

GONADOTROPIN-RELEASING HORMONE RECEPTOR

TARGET -> AGONIST

Amount:


					JD54DU77I8

FERTIRELIN ACETATE

SALT/SOLVATE -> PARENT

Related Record Type Details


					Q041AO6T91

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_9]		P		L-PROLINE ETHYLAMIDE	16B70W94PN
AMINO_ACID_SUBSTITUTION	[1_1]		Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:CALCULATED	CHEMICAL