BENZYLTHIOURACIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H10N2OS
Molecular Weight	218.275
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NC(=S)NC(CC2=CC=CC=C2)=C1

InChI

InChIKey=PNXBXCRWXNESOV-UHFFFAOYSA-N

InChI=1S/C11H10N2OS/c14-10-7-9(12-11(15)13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H10N2OS
Molecular Weight	218.275
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18774123 | https://www.ncbi.nlm.nih.gov/pubmed/27126427 | DOI: 10.1007/s40278-018-48731-1 | https://www.ncbi.nlm.nih.gov/pubmed/7504976 | https://www.ncbi.nlm.nih.gov/pubmed/12428490

Benzylthiouracil is a drug with anti-thyroid activity. It was developed for the treatment of multinodular goiter and hyperthyroidism. Benzylthiouracil treatment associated with severe adverse effects. It has been observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. Benzylthiouracil induced ANCA associated glomerulonephritis in patients with Graves' disease. Benzylthiouracil induces toxic hepatitis and lung damage.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:43:40 GMT 2025` Edited by `admin` on `Mon Mar 31 18:43:40 GMT 2025`
Record UNII	PZ35LUM333
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BASDENE

Preferred Name

English

BENZYLTHIOURACIL

Systematic Name

English

NSC-39511

Code

English

BENTIURACIL

Common Name

English

6-BENZYL-2-THIOURACIL

Systematic Name

English

Benzylthiouracil [WHO-DD]

Common Name

English

BENZYLTHIOURACIL [MART.]

Common Name

English

4(1H)-PYRIMIDINONE, 2,3-DIHYDRO-6-(PHENYLMETHYL)-2-THIOXO-

Systematic Name

English

NSC-6508

Code

English

Classification Tree Code System Code

WHO-VATC

QH03BA03