Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H21F2N3OS.ClH |
Molecular Weight | 437.934 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.FC1=CC(F)=C2OC[C@@H](CC2=C1)N3C(=S)NC=C3CCNCC4=CC=CC=C4
InChI
InChIKey=OIXMDJZVHVPBNM-GMUIIQOCSA-N
InChI=1S/C21H21F2N3OS.ClH/c22-16-8-15-9-18(13-27-20(15)19(23)10-16)26-17(12-25-21(26)28)6-7-24-11-14-4-2-1-3-5-14;/h1-5,8,10,12,18,24H,6-7,9,11,13H2,(H,25,28);1H/t18-;/m1./s1
Molecular Formula | C21H21F2N3OS |
Molecular Weight | 401.473 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Zamicastat (also known as BIA 5-1058) is a dopamine β-hydroxylase (DβH) inhibitor that decreases noradrenaline and increases dopamine levels in peripheral sympathetically innervated tissues. It is known that the use of DβH inhibitors is a promising approach to treat hypertension, heart failure and cardiovascular diseases where a reduction in the sympathetic tone has beneficial effects. Zamicastat participated in phase II clinical trials in pulmonary arterial hypertension as adjuvant therapy in Austria. In addition, the drug successfully completed phase I in patients with hypertension and chronic heart failure.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02151994
BIA 5-1058 (Zamicastat) (5, 25 and 100 mg) tablets
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:26:25 GMT 2023
by
admin
on
Sat Dec 16 05:26:25 GMT 2023
|
Record UNII |
PXQ9G79I10
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
PXQ9G79I10
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY | |||
|
100000177203
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY | |||
|
DTXSID40160652
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY | |||
|
1383828-47-4
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY | |||
|
DBSALT002186
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY | |||
|
25156755
Created by
admin on Sat Dec 16 05:26:25 GMT 2023 , Edited by admin on Sat Dec 16 05:26:25 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |