BOMBESIN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C71H110N24O18S
Molecular Weight	1619.848
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)C(C)C)C(N)=O

InChI

InChIKey=QXZBMSIDSOZZHK-DOPDSADYSA-N

InChI=1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C71H110N24O18S
Molecular Weight	1619.848
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	12 / 12
E/Z Centers	8
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/31082173 | https://www.ncbi.nlm.nih.gov/pubmed/3008115 | https://www.ncbi.nlm.nih.gov/pubmed/11803457

Bombesin (BN), a neuropeptide that originally was purified from the skin of the European frog (Bombina bombina). It has many biological effects including hormone release, stimulation of pancreatic enzyme secretion, gallbladder contraction and bronchoconstriction. Bombesin is a highly specific marker of neuroendocrine differentiation and thus a valuable tumor marker. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.

Approval Year

PubMed

Title	Date	PubMed
Bombesin in human neuroendocrine (NE) neoplasms.	1985	3008115
The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines.	1999 Dec	10636070
Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice.	2000 Nov	11127929
Regulation and signaling of human bombesin receptors and their biological effects.	2009 Feb	19115523

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:19 UTC 2023` Edited by `admin` on `Fri Dec 15 16:26:19 UTC 2023`
Record UNII	PX9AZU7QPK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BOMBESIN

Common Name

English

PGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2

Common Name

English

5-OXO-PRO-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2

Common Name

English

ALYTESIN, 2-L-GLUTAMINE-6-L-ASPARAGINE-

Common Name

English

L-METHIONINAMIDE, 5-OXO-L-PROLYL-L-GLUTAMINYL-L-ARGINYL-L-LEUCYLGLYCYL-L-ASPARAGINYL-L-GLUTAMINYL-L-TRYPTOPHYL-L-ALANYL-L-VALYLGLYCYL-L-HISTIDYL-L-LEUCYL-

Common Name

English

BOMBESIN 14

Common Name

English

BOMBESIN [MI]

Common Name

English

Classification Tree Code System Code

LOINC

10874-6