Empasiprubart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:35:50 GMT 2025` Edited by `admin` on `Wed Apr 02 13:35:50 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	PVA73UA67L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Empasiprubart

Official Name

English

ARGX-117

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens C2 (complement 2)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-447) [VH humanized (Homo sapiens IGHV1-8*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118)

Common Name

English

Immunoglobulin G1 [235-alanine,236-alanine,434-lysine,435-phenylalanine], anti-(human complement component 2) (human monoclonal ARGX-117 ?1-chain), disulfide with human monoclonal ARGX-117 ?-chain, dimer

Common Name

English

ARGX117

Code

English

EMPASIPRUBART [USAN]

Common Name

English

empasiprubart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

PVA73UA67L

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

PRIMARY

USAN

MN-180

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

PRIMARY

INN

12277

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

PRIMARY

SMS_ID

300000013680

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

PRIMARY

CAS

2579031-19-7

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

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NCI_THESAURUS

C190478

Created by admin on Wed Apr 02 13:35:50 GMT 2025 , Edited by admin on Wed Apr 02 13:35:50 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_218
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_221	3_218
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					PVA73UA67L

ACTIVE MOIETY

Comments:

Binding to its target C2 and binds specifically to C2b, thereby blocking downstream complement activation.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL