Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.6377 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H](CCC=C(C)C)[C@H]1CC[C@H]2C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](O)C[C@@H]4CC3
InChI
InChIKey=CGSJXLIKVBJVRY-XTGBIJOFSA-N
InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1
| Molecular Formula | C27H44O |
| Molecular Weight | 384.6377 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010-08 |
|
| Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. | 2010-04 |
|
| Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009-12-30 |
|
| Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. | 2009-10-05 |
|
| Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. | 2009-07-15 |
|
| Differences in sterol composition between male and female gonads of dominant limpet species. | 2009-07 |
|
| Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. | 2009-04-20 |
|
| Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3. | 2009-02-06 |
|
| Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009-01-15 |
|
| Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 |
|
| Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis. | 2008-09-15 |
|
| Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. | 2008-08-06 |
|
| Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. | 2008-03 |
|
| Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. | 2008 |
|
| Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. | 2008 |
|
| Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. | 2008 |
|
| Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. | 2007-05-09 |
|
| Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. | 2006-09-22 |
|
| Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes. | 2006-08-15 |
|
| Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. | 2006-08-04 |
|
| Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. | 2006-08 |
|
| Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006-05-23 |
|
| Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei. | 2006-03-10 |
|
| The activity reaction core and plasticity of metabolic networks. | 2005-12 |
|
| Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. | 2005-10-28 |
|
| Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. | 2005-07 |
|
| YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae. | 2005-04-08 |
|
| Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme. | 2005-02 |
|
| The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). | 2004-11-08 |
|
| Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. | 2004-11-01 |
|
| Oxysteroids: a new class of steroids with autocrine and paracrine functions. | 2004-10 |
|
| Integrated analysis of metabolic phenotypes in Saccharomyces cerevisiae. | 2004-09-08 |
|
| Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights. | 2004-08 |
|
| Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain. | 2004-08 |
|
| Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003-12-01 |
|
| Sterol methyltransferase2: purification, properties, and inhibition. | 2003-12-01 |
|
| Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003-10 |
|
| Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. | 2003-09 |
|
| Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. | 2003-05-30 |
|
| SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. | 2003-02-10 |
|
| Active site mapping and substrate channeling in the sterol methyltransferase pathway. | 2002-11-08 |
|
| Purification, characterization and catalytic properties of human sterol 8-isomerase. | 2002-11-01 |
|
| Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. | 2002-08 |
|
| Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. | 2002-07-19 |
|
| [Novel synthesis of zymosterol]. | 2002-06-25 |
|
| The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. | 2002-05 |
|
| The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. | 2001-04-20 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:37:53 GMT 2025
by
admin
on
Mon Mar 31 19:37:53 GMT 2025
|
| Record UNII |
PU2755PT4O
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| Record Status |
Validated (UNII)
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| Record Version |
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92746
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PU2755PT4O
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ZYMOSTEROL
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