Torulimogene Lonferencel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 10:49:48 GMT 2025` Edited by `admin` on `Wed Apr 02 10:49:48 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	KILLED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	embryonic kidney cell
Record UNII	PRT7W2L4WZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Torulimogene Lonferencel

Official Name

English

irradiated human embryonic kidney cells (cell line HEK293) transfected with three self-inactivating, non-replicating lentiviral vectors individually expressing (i) codon-optimised Wilms tumour protein 1 (WT1) isoform D, (ii) codon-optimised cluster of di

Preferred Name

English

torulimogene lonferencel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203068

Created by admin on Wed Apr 02 10:49:48 GMT 2025 , Edited by admin on Wed Apr 02 10:49:48 GMT 2025

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FDA UNII

PRT7W2L4WZ

Created by admin on Wed Apr 02 10:49:48 GMT 2025 , Edited by admin on Wed Apr 02 10:49:48 GMT 2025

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INN

12385

Created by admin on Wed Apr 02 10:49:48 GMT 2025 , Edited by admin on Wed Apr 02 10:49:48 GMT 2025

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SMS_ID

300000054867

Created by admin on Wed Apr 02 10:49:48 GMT 2025 , Edited by admin on Wed Apr 02 10:49:48 GMT 2025

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Related Record Type Details


					PRT7W2L4WZ

Torulimogene Lonferencel

ACTIVE MOIETY

Comments:

ASP7517 is expected to have effects against WT1-expressing tumors by inducing both natural killer (NK) cell activity (innate immunity) and WT1-specific T cell activity (adaptive immunity)

Interaction Type:

IN-VITRO, IN-VIVO

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
		CHEMICAL	ALPHA-GALACTOSYLCERAMIDE	WX671898JF
		CHEMICAL	DOXYCYCLINE	N12000U13O
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Torulimogene lonferencel rtTA vector	SHM2BH7BDK
	INACTIVATION	PHOTOCHEMICAL	UNSPECIFIED SUBSTANCE	26cec4c2
LENTIVIRAL TRANSFECTION	TRANSFECTION		Torulimogene lonferencel WT1 vector	2LL2YKR3G2
LENTIVIRAL TRANSFECTION	TRANSFECTION		Torulimogene lonferencel 1d vector	FN2DB7C5CS

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					WILMS TUMOR PROTEIN ISOFORM D	WYG87YV56T