Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H15NO3S |
| Molecular Weight | 217.285 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H](CS)C(=O)N1CCC[C@H]1C(O)=O
InChI
InChIKey=FAKRSMQSSFJEIM-BQBZGAKWSA-N
InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7-/m0/s1
| Molecular Formula | C9H15NO3S |
| Molecular Weight | 217.285 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
http://www.nevapress.com/cdr/full/17/2/115.pdf | https://www.ncbi.nlm.nih.gov/pubmed/8138187
Curator's Comment: The description was created based on several sources, including
http://www.nevapress.com/cdr/full/17/2/115.pdf | https://www.ncbi.nlm.nih.gov/pubmed/8138187
Epicaptopril is an impurity of Captopril, which is an orally active angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and congestive heart failure. Epicaptopril does not show any inhibition of angiotensin-converting enzyme (ACE), and can be used as negative control in ACE inhibition experiments
Approval Year
Sample Use Guides
The protective effects of SH-ACEIs from free radical-induced cell damage have been also assessed in cultured endothelial cells exposed to a superoxide anion and hydroxyl radicals generating system. Preincubation of the cells with captopril, epicaptopril, or zofenopril produced a concentration-dependent (10–200 mkM) inhibition of malonyldialdehyde formation. Both loss of cell viability and membrane blebbing were reduced by SH-ACEIs at concentrations as low as 10 mkM. In contrast, lisinopril and enalaprilat at concentrations up to 200 mkM were ineffective
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:56:33 GMT 2025
by
admin
on
Mon Mar 31 20:56:33 GMT 2025
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| Record UNII |
PPW0ENH1HA
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| Record Status |
Validated (UNII)
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DTXSID60212642
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PPW0ENH1HA
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