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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H23N7O6.H2O4S
Molecular Weight 555.518
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ARFOLITIXORIN MONOSULFATE

SMILES

OS(O)(=O)=O.[H][C@@]12CN(CN1C3=C(NC2)NC(N)=NC3=O)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

InChIKey=GKJSPWCDMPVQHB-KZCZEQIWSA-N
InChI=1S/C20H23N7O6.H2O4S/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29;1-5(2,3)4/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31);(H2,1,2,3,4)/t12-,13+;/m1./s1

HIDE SMILES / InChI

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C20H23N7O6
Molecular Weight 457.4399
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

METHYLENETETRAHYDROFOLIC ACID, L-(+), an endogenous biomodulator that was developed under the brand name modufolin or arfolitixorin by the Isofol Medical. Arfolitixorin is developed to increase the efficacy of standard of care chemotherapy for advanced colorectal cancer. This drug is currently being studied in a global phase 3 clinical trial. Besides, the drug successfully completed phase II as rescue therapy for osteosarcoma. 21 May 2019 Isofol Medical has received clinical patent protection for the arfolitixorinin USA. It relates to a method of increasing blood concentration of deoxyuridine, a blood biomarker for inhibition of tumor growth in human cancer treatment.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

IV injection every second week for 8 weeks 30 to 240 mg/m2
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Thu Jul 06 19:56:06 UTC 2023
Edited
by admin
on Thu Jul 06 19:56:06 UTC 2023
Record UNII
PO4XPF4TIX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ARFOLITIXORIN MONOSULFATE
Common Name English
L-GLUTAMIC ACID, N-(4-((6AR)-3-AMINO-1,2,5,6,6A,7-HEXAHYDRO-1-OXOIMIDAZO(1,5-F)PTERIDIN-8(9H)-YL)BENZOYL)-, SULFATE (1:1)
Systematic Name English
L-GLUTAMIC ACID, N-(4-(3-AMINO-1,2,5,6,6A,7-HEXAHYDRO-1-OXOIMIDAZO(1,5-F)PTERIDIN-8(9H)-YL)BENZOYL)-, (R)-, SULFATE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
137331911
Created by admin on Thu Jul 06 19:56:07 UTC 2023 , Edited by admin on Thu Jul 06 19:56:07 UTC 2023
PRIMARY
FDA UNII
PO4XPF4TIX
Created by admin on Thu Jul 06 19:56:07 UTC 2023 , Edited by admin on Thu Jul 06 19:56:07 UTC 2023
PRIMARY
CAS
149930-93-8
Created by admin on Thu Jul 06 19:56:07 UTC 2023 , Edited by admin on Thu Jul 06 19:56:07 UTC 2023
PRIMARY
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