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Details

Stereochemistry ACHIRAL
Molecular Formula C19H22N2O.ClH
Molecular Weight 330.852
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NOXIPTILINE HYDROCHLORIDE

SMILES

Cl.CN(C)CCON=C1C2=CC=CC=C2CCC3=CC=CC=C13

InChI

InChIKey=JIKBYFBMUAUPJS-UHFFFAOYSA-N
InChI=1S/C19H22N2O.ClH/c1-21(2)13-14-22-20-19-17-9-5-3-7-15(17)11-12-16-8-4-6-10-18(16)19;/h3-10H,11-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula C19H22N2O
Molecular Weight 294.3908
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Noxiptiline (brand names Agedal, Elronon, Nogedal), is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. In a double-blind comparison of noxiptiline and amitriptyline in hospitalized patients with primary depressive illness for 3-6 weeks there were no significant differences, but noxiptiline had a faster onset of action. A comparison with imipramine also showed no difference in therapeutic efficacy. As regards adverse effects, noxiptiline seemed to cause more mental symptoms, such as delirium. In one study in 44 patients, 9 developed delirium, there were mild manic symptoms in 6, dry mouth in 21, disturbed micturition in 2. and difficulty in accommodation in 3.

Approval Year

PubMed

PubMed

TitleDatePubMed
Trabecular shear stresses predict in vivo linear microcrack density but not diffuse damage in human vertebral cancellous bone.
2003 Jun
Urine sample preparation of tricyclic antidepressants by means of a supported liquid membrane technique for high-performance liquid chromatographic analysis.
2004 Mar 5
[Results of adjuvant intravesical Bacillus Calmette-Guérin therapy for grade 3 superficial bladder cancer].
2004 Nov
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:37:50 UTC 2023
Edited
by admin
on Fri Dec 15 18:37:50 UTC 2023
Record UNII
PNW59W2B94
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NOXIPTILINE HYDROCHLORIDE
WHO-DD  
Common Name English
NOGEDAL
Brand Name English
AGEDAL
Brand Name English
CD 37B
Code English
NOXIPTILIN HYDROCHLORIDE [MI]
Common Name English
Noxiptiline hydrochloride [WHO-DD]
Common Name English
5H-DIBENZO(A,D)CYCLOHEPTEN-5-ONE, 10,11-DIHYDRO-, O-(2-(DIMETHYLAMINO)ETHYL)OXIME, MONOHYDROCHLORIDE
Common Name English
CD-37B
Code English
Code System Code Type Description
EVMPD
SUB03469MIG
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
CAS
4985-15-3
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
SMS_ID
100000085726
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
PUBCHEM
21086
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
ECHA (EC/EINECS)
225-638-9
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
EPA CompTox
DTXSID70964448
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
FDA UNII
PNW59W2B94
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY
MERCK INDEX
m854
Created by admin on Fri Dec 15 18:37:50 UTC 2023 , Edited by admin on Fri Dec 15 18:37:50 UTC 2023
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE