THROMBOXANE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H40O
Molecular Weight	296.531
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC

InChI

InChIKey=RZWIIPASKMUIAC-VQTJNVASSA-N

InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H40O
Molecular Weight	296.531
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C.	2001-05-18	11278299
Substrate binding is the rate-limiting step in thromboxane synthase catalysis.	2001-05-04	11297515
Role of nitric oxide (NO) in pulmonary dysfunction associated with experimental cirrhosis.	2001-05	11311311
Sites and ionic mechanisms of hypoxic vasoconstriction in frog skin.	2001-05	11294748
Mariannaepyrone--a new inhibitor of thromboxane A2 induced platelet aggregation.	2001-04-17	11302199
A coculture model of intrahepatic islet transplantation: activation of Kupffer cells by islets and acinar tissue.	2001-04-11	11294466
Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants.	2001-04	11312628
Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation.	2001-04	11310850
Characterization of the effects of isoprostanes on platelet aggregation in human whole blood.	2001-04	11309241
Inhibition of platelet activation in stroke-prone spontaneously hypertensive rats: comparison of losartan, candesartan, and valsartan.	2001-04	11300653
Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes.	2001-04	11285308
Prostaglandin inhibition by intraperitoneal indomethacin has no effect on peritoneal permeability during stable CAPD.	2001-04	11274278
Microvascular endothelial dysfunction and its mechanism in a rat model of subarachnoid hemorrhage.	2001-04	11273938
Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge.	2001-04	11264251
Determinants of enhanced thromboxane biosynthesis in renal transplantation.	2001-04	11260423
Mesangial cells release untransformed prostaglandin H2 as a major prostanoid.	2001-04	11260389
Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin.	2001-04	11259536
Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus.	2001-04	11259259
Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase.	2001-04	11238006
Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1beta in perfused rat lungs.	2001-04	11237998
Effect of 8-iso-prostaglandin F(2 alpha) on acetylcholine release from parasympathetic nerves in guinea pig airways.	2001-03-30	11290373
Involvement of prostanoid release in the mediation of UTP-induced cerebrovascular contraction in the rat.	2001-03-30	11277988
Comparison between nonpulsatile and pulsatile machine perfusion preservation in liver transplantation from non-heart-beating donors.	2001-03-27	11267136
Elimination of Kupffer cells suppresses activation of nuclear factor kappa B and production of cytokines and eicosanoids in non-heart-beating donors.	2001-03-27	11267090
Effects of nickel chloride on human platelets: enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid.	2001-03-23	11289317
Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells.	2001-03	11310828
Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix.	2001-03	11305693
L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats.	2001-03	11288812
Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation.	2001-03	11284447
Characterization of increased cough sensitivity after antigen challenge in guinea pigs.	2001-03	11260161
Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca2+ ionophores.	2001-03	11260060
Antigen-induced bronchial hyperreactivity and bronchopulmonary inflammation in rats: effect of TNF receptor binding protein.	2001-03	11258800
Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors.	2001-03	11250881
Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.	2001-03	11238561
Rofecoxib, a COX-2 inhibitor, does not inhibit human gastric mucosal prostaglandin production.	2001-03	11231941
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.	2001-02-26	11229777
Thromboxane A2 release in ischemia and reperfusion of free flaps in rats, studied by microdialysis.	2001-02	11310752
Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway.	2001-02	11246558
Genetic and pharmacological analyses of involvement of Src-family, Syk and Btk tyrosine kinases in platelet shape change. Src-kinases mediate integrin alphaIIb beta3 inside-out signalling during shape change.	2001-02	11246557
Evidence for platelet alphaIIb beta3 activation despite elevated cytosolic cAMP.	2001-02	11246555
Low molecular weight heparin reduces proteinuria and modulates glomerular TNF-alpha production in the early phase of adriamycin nephropathy.	2001-02	11244311
Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids.	2001-02	11237476
Cardiac ischemic preconditioning improves lung preservation in valve replacement operations.	2001-02	11235719
Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity.	2001-01-26	11228102
[Update on the treatment with platelet antiaggregation agents].	2001-01	11291339
Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin.	2001-01	11280644
Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components.	2001-01	11227032
Sixth international workshop on scleroderma research, Oxford, UK, 30 July--22 August 2000.	2001	11269238
Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection.	2001	11234698
Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.	2001	11228592

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 10:55:00 GMT 2025` Edited by `admin` on `Wed Apr 02 10:55:00 GMT 2025`
Record UNII	PLB95F606Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THROMBOXANE

Systematic Name

English

HOMO-11A-OXAPROSTANE

Preferred Name

English

(2R-TRANS)-3-HEPTYLTETRAHYDRO-2-OCTYL-2H-PYRAN

Systematic Name

English

2H-PYRAN, 3-HEPTYLTETRAHYDRO-2-OCTYL-, (2R,3S)-

Systematic Name

English

Code System Code Type Description

CAS

66719-58-2