MIBAVADEMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:10:09 GMT 2025` Edited by `admin` on `Wed Apr 02 01:10:09 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	PHL2UDY3AB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MIBAVADEMAB

Official Name

English

REGN-4461

Preferred Name

English

IMMUNOGLOBULIN G4 (227-PROLINE), ANTI-(HUMAN LEPTIN RECEPTOR) (HUMAN MONOCLONAL REGN4461 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL REGN4461 .KAPPA.-CHAIN, DIMER

Common Name

English

REGN4461

Code

English

mibavademab [INN]

Common Name

English

Code System Code Type Description

INN

11510

Created by admin on Wed Apr 02 01:10:09 GMT 2025 , Edited by admin on Wed Apr 02 01:10:09 GMT 2025

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INN

SMS_ID

300000005382

Created by admin on Wed Apr 02 01:10:09 GMT 2025 , Edited by admin on Wed Apr 02 01:10:09 GMT 2025

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FDA UNII

PHL2UDY3AB

Created by admin on Wed Apr 02 01:10:09 GMT 2025 , Edited by admin on Wed Apr 02 01:10:09 GMT 2025

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CAS

2305770-44-7

Created by admin on Wed Apr 02 01:10:09 GMT 2025 , Edited by admin on Wed Apr 02 01:10:09 GMT 2025

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NCI_THESAURUS

C179103

Created by admin on Wed Apr 02 01:10:09 GMT 2025 , Edited by admin on Wed Apr 02 01:10:09 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_133	4_215
2_146	2_202
2_260	2_320
1_133	3_215
2_366	2_424
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195
1_146	1_202
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					26Y0IW6T5O

LEPTIN RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					PHL2UDY3AB

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL