RETINOID X RECEPTOR ALPHA

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:02:59 UTC 2023` Edited by `admin` on `Sat Dec 16 15:02:59 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	PG6GA793XH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RETINOID X RECEPTOR ALPHA

Common Name

English

NR2B1

Common Name

English

RETINOIC ACID RECEPTOR RXR-ALPHA

Common Name

English

RXRA

Common Name

English

NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 1

Common Name

English

RXR.ALPHA.

Common Name

English

Code System Code Type Description

UNIPROT

P19793

Created by admin on Sat Dec 16 15:02:59 UTC 2023 , Edited by admin on Sat Dec 16 15:02:59 UTC 2023

PRIMARY

FDA UNII

PG6GA793XH

Created by admin on Sat Dec 16 15:02:59 UTC 2023 , Edited by admin on Sat Dec 16 15:02:59 UTC 2023

PRIMARY

Linkage Type	Residue Index
COORDINATION COMPOUND	1_135	1_138	1_152	1_155
COORDINATION COMPOUND	1_171	1_177	1_187	1_190

Related Record Type Details


					LCH760E9T7

ACITRETIN

INHIBITOR -> TARGET

Amount:


					0462Z4S4OZ

OBETICHOLIC ACID

INHIBITOR -> TARGET

Interaction Type:

INHIBITOR

Qualification:

EC50

Amount:


					877M97Z38Y

VTP-194204

AGONIST -> TARGET


					1UA8E65KDZ

ALITRETINOIN

AGONIST -> TARGET

Amount:


					4S7931G4PP

K-80003

INHIBITOR -> TARGET

Comments:

Inhibits the interaction of the N-terminally truncated RXRα (tRXRα) with the p85α subunit of PI3K, leading to suppression of AKT activation and induction of apoptosis.

Interaction Type:

ALLOSTERIC INHIBITOR


					A61RXM4375

BEXAROTENE

AGONIST -> TARGET

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL