Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H28N2O.ClH |
Molecular Weight | 324.889 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCCN1CCCC1C(=O)NC2=C(C)C=C(C)C=C2C
InChI
InChIKey=NFEZGTHMTGKIBG-UHFFFAOYSA-N
InChI=1S/C18H28N2O.ClH/c1-5-6-9-20-10-7-8-16(20)18(21)19-17-14(3)11-13(2)12-15(17)4;/h11-12,16H,5-10H2,1-4H3,(H,19,21);1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C18H28N2O |
Molecular Weight | 288.4277 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Bumecaine (Pyromecaine) is a local anesthetic and anti-arrhythmic drug. It is indicated as an agent for superficial anesthesia during medical and diagnostic procedures in dentistry, ophthalmology, otorhinolaryngology, surgery, bronchology, gastroenterology, urology. The experiments on the isolated neurons in the rat spinal ganglions have shown that interaction of pyromecaine with inactivated Na+ channels makes a considerable contribution to the blocking effect of anesthesia. Oral administration of pyromecaine pills considerably depresses platelet aggregation and even causes platelet disaggregation. Possible side effects are: general weakness, nausea, vomiting, headache, dizziness, fainting, a drop in blood pressure. Quinidine increases the risk of side effects.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Sodium channels |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Bumecain Approved UsePyromecaine is prescribed as an anesthetic for superficial anesthesia during medical and diagnostic procedures in dentistry, ophthalmology, otorhinolaryngology, surgery, bronchology, gastroenterology, urology. Pyromecaine is also used as an antiarrhythmic agent. |
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Primary | Bumecain Approved UsePyromecaine is prescribed as an anesthetic for superficial anesthesia during medical and diagnostic procedures in dentistry, ophthalmology, otorhinolaryngology, surgery, bronchology, gastroenterology, urology. Pyromecaine is also used as an antiarrhythmic agent. |
PubMed
Title | Date | PubMed |
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[Anti-arrhythmia properties of pyromecaine]. | 1983 Sep-Oct |
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[Effect of anti-angina therapy on phospholipid levels of the myocardium in ischemic lesions]. | 1988 Oct |
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[The action of aqueous solutions of dicaine and pyromecaine on the epithelium of the oral mucosa]. | 1990 May-Jun |
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[A morphological evaluation of the tissue status of the oral mucosa after anesthesia applied with dicaine and pyromecaine solutions]. | 1990 Nov-Dec |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:01:20 GMT 2023
by
admin
on
Sat Dec 16 02:01:20 GMT 2023
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Record UNII |
PBE1H9OIFQ
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID00940679
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19089-24-8
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167785
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Related Record | Type | Details | ||
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ACTIVE MOIETY |