SB-243213

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H19F3N4O2.ClH
Molecular Weight	464.868
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=CC2=C(C=C1C(F)(F)F)N(CC2)C(=O)NC3=CN=C(OC4=C(C)N=CC=C4)C=C3

InChI

InChIKey=OOOGUILTDUSZPA-UHFFFAOYSA-N

InChI=1S/C22H19F3N4O2.ClH/c1-13-10-15-7-9-29(18(15)11-17(13)22(23,24)25)21(30)28-16-5-6-20(27-12-16)31-19-4-3-8-26-14(19)2;/h3-6,8,10-12H,7,9H2,1-2H3,(H,28,30);1H

HIDE SMILES / InChI

Molecular Formula	C22H19F3N4O2
Molecular Weight	428.4071
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2c (5-HT2c) receptor 124 Target ID: CHEMBL225 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11489455	Inverse Agonist 80		9.37 null [pKi]

PubMed

Title	Date	PubMed
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.	2000 Mar 23	10737744
SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety.	2001 Aug	11489455
Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine.	2002 Apr	11888551
Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat.	2006 Dec 28	17059817
Selective activation of 5-HT(2C) receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study.	2007 Feb 23	17161544

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:37:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:53 GMT 2023`
Record UNII	PA86JD65ZJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SB-243213

Code

English

1H-INDOLE-1-CARBOXAMIDE, 2,3-DIHYDRO-5-METHYL-N-(6-((2-METHYL-3-PYRIDINYL)OXY)-3-PYRIDINYL)-6-(TRIFLUOROMETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

5-METHYL-1-((-2-((2-METHYL-3-PYRIDYL)OXY)-5-PYRIDYL)CARBAMOYL)-6-TRIFLUOROMETHYLINDOLINE HYDROCHLORIDE

Systematic Name

English

SB-243213A

Code

English

Code System Code Type Description

CAS

200940-23-4