Varnimcabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 14:35:16 GMT 2025` Edited by `admin` on `Wed Apr 02 14:35:16 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	t lymphocytes (enriched for cd4/cd8)
Record UNII	PA5M8REK2P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Varnimcabtagene Autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor targeting CD19. The expressed transgene comprises a CD8? le

Preferred Name

English

varnimcabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000038935

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

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INN

12208

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

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NCI_THESAURUS

C179725

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

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FDA UNII

PA5M8REK2P

Created by admin on Wed Apr 02 14:35:16 GMT 2025 , Edited by admin on Wed Apr 02 14:35:16 GMT 2025

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Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					PA5M8REK2P

Varnimcabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN IL-15	HRJ300HC9W
CULTURE	EXPANSION	BIOLOGICAL	INTERLEUKIN-7 (NONGLYCOSYLATED)	8FA908P5W4
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Varnimcabtagene autoleucel lentiviral vector	53N2K5DN8U
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Varnimcabtagene autoleucel transgene insert	N5FUK5M3AP
VECTOR EXPRESSED PROTEIN					Varnimcabtagene autoleucel CAR-T receptor	RB89T79UXJ