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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 22:36:44 GMT 2025
Edited
by admin
on Tue Apr 01 22:36:44 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type BISPECIFIC T CELL ENGAGER
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
P9I9Z3MF7Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMG 427
Preferred Name English
Emirodatamab
INN   USAN  
Official Name English
EXTENDED HALF-LIFE ANTI-FLT3 X ANTI-CD3 BITE (BISPECIFIC T CELL ENGAGER) ANTIBODY CONSTRUCT
Common Name English
AMG-427
Code English
ANTI-FLT3/CD3 BITE ANTIBODY AMG 427
Common Name English
emirodatamab [INN]
Common Name English
EMIRODATAMAB [USAN]
Common Name English
Immunoglobulin, bispecific, anti-(human fms-like tyrosine kinase FLT3) (human monoclonal FLT3_bispecific_1 single-chain variable fragment VH1-(GGGGS)3-VL1) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin anti-(human CD3 anti
Common Name English
Immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens FLT3 (fms related receptor tyrosine kinase 3, STK1, FLK2, CD135)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], single chain monoclonal antibody, bispecific; scFv-scFv-scFc fused single chain (1-989)
Common Name English
Emirodatamab [WHO-DD]
Common Name English
Code System Code Type Description
CAS
2449199-61-3
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY
INN
12028
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY
FDA UNII
P9I9Z3MF7Z
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY
USAN
LM-112
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY
SMS_ID
300000028691
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY
NCI_THESAURUS
C156399
Created by admin on Tue Apr 01 22:36:44 GMT 2025 , Edited by admin on Tue Apr 01 22:36:44 GMT 2025
PRIMARY NCIT
From To
1_22 1_97
1_46 1_239
1_162 1_227
1_274 1_350
1_414 1_482
1_511 1_768
1_514 1_771
1_546 1_587
1_577 1_606
1_652 1_710
1_803 1_844
1_834 1_863
1_909 1_967
Related Record Type Details
RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3
TARGET->LIGAND
CD3
CD3
TARGET -> ACTIVATOR
RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 D835Y
TARGET->LIGAND
Related Record Type Details
Emirodatamab
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_989] C-TERMINUS LYSINE K3Z4F929H6
AMINO_ACID_SUBSTITUTION [1_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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